Background & Aim: Menopause has been recognized as a critical stage in women’s life which has a significant impact on their quality of life. This study aimed to evaluate the impact of educational interventions based on individual empowerment model on knowledge, attitude, self efficacy, self-esteem and quality of life of postmenopausal women.Material & Methods: In a quasi-experimental study, 100 women covered by health care centers in Qazvin were randomly assigned to either experimental or control group. The data gathering tool included a demographic questionnaire, the Rosenberg Self-esteem questionnaire, self efficacy scale, Knowledge and attitude questionnaire and menopause-specific quality of life questionnaire (26 items). The procedure for experimental group consisted of five group discussions for 60-45 minutes according to empowerment model. Data were collected before and 3 months after intervention and analyzed by independent and paired t-test and chi-square using SPSS-PC (v.17.0).Results: After education, mean scores of knowledge (from 38.11±8.43 to 49.14±9.23), attitude (from 14.43±4.31 to 19.32±5.54), self- esteem (from 13.82±4.47 to 17.90±5.61) and self efficacy (from 14.42±5.43 to 20.06±6.12) increased significantly in the experimental group (P<0.001). Moreover, results showed a significant and positive reduction in the quality of life of the experimental group after empowerment program (P<0.001).Conclusion: Training programs using empowerment model to improve the quality of life of postmenopausal women is recommended.