Background and aims: Occupational musculoskeletal disorders (MSDs) are major cause of disability and loss of productivity in developed countries. One of the risk factors of these abnormalities is overweight; therefore the purpose of this study was to assess the quantitative and qualitative musculoskeletal disorders of workers and its relationship with the body mass index (BMI). Methods: The industry had 1, 473 staffs of which 520 individuals with at least one year of experience were randomly selected from different units and shifts in this cross-sectional study. After receiving full consent they responded to NORDIC and LPD questionnaires. For validity and reliability of questionnaires Chronbach’ s alpha was used. Ultimately, to determine the relationship between musculoskeletal disorders and with body mass index Chi-square, regression and correlation tests were performed using SPSS version 19. In this study, l0. 05 was considered as leve of significance. Results: This study showed there was no slim participants regarding BMI index, though 32% were normal, 41% overweight and 27% were obese. Between lower and upper limb, knee, shoulder, hip and hand, also in elbow and ankle organs were significant relationship and and association between BMI and musculoskeletal disorders in the upper limbs and lower back, knee, shoulder and hip were also significant. Conclusion: Since the musculoskeletal disorders increase with the increase of age, experience, daily working hours and second jobs. For obviation these disorders and discomforts proper diet regime is recommended along with ergonomics training for workers. Also, we suggest further research in this base using Localized Postural Discomfort questionnaire.