Weather is one of the most important factors affecting on human being’s life aspects, especially in health and comfort. If the man-made buildings are compatible with weather condition, they not only provide his/her comfort but also decrease the energy consumption. In this study, in order to evaluate the climate and architecture of Khorramabad city, a veriaty of obtained information including temperature, precipitation, wind, relative humidity, effective architecture indices, Olgi, Mahoney and Gioony have been employed. The results show that the thermal comfort in nights is not at ideal zone while is at comfort zone in most of the days of months. Moreover, the months of October, January, February, March and November are out of comfort zone, cold is predominant in these months and using heating systems are needed. In contrast to aforementioned months; July, August and September are in comfort zone. Of note, the weather of June, July, August and September is hot, lacking of comfort in days and using chillers and ventilators are required. In order to depict of thermal comfort of each indices, comparative table has been used for simplicity.