Avicenna Journal of Clinical Medicine
Year:2001 | Volume:8 | Issue:1 (SN 19)|Papers Count:14

Since of seizures in epileptic is in childhood in 80% of cases and 10 to 20% of these seizures are refractory to treatment, this study was performed to compare the efficacy of intravenous gammaglobuline with ketogenic diet in the treatment of refractory epilepsy in children. A clinical trial research was conducted on 40 children with recalcitrant epilepsy referred to Mophid Children Hospital in 1994. The children were devided to two "Case" and "Control" groups at random after partial matching. Children in the case group were treated by IV gammaglobuline at a dose of 4oo mg/kg/dose each three to four weeks for four to six times and those in the control group by mixed Ketogenic diet. The frequency and duration of seizure, electroencephalografic and behavioral changes before and after therapy were recorded and the result were evaluated. There was a 52% and 64% decrease in the average frequency of seizures per 24-hour in the case and control groups, respectively. The difference was not statistically significant. The duration of seizures was decreased in 45% and 60% of the case and control groups respectively. Since there was no significant difference in the efficacy of these two therapeutic modalities and considering the easier and the modalities , and considering the easier and the more tolerable nature of IV gammaglobuline, this method can be used as a therapeutic modality in recalcitrant epilepsy.

Functional dyspepsia found in 25% of the general population and a large number of patients referred to the health centers. Treatment of this disease with promotility drugs is not effective, and is so expensive too. Evaluation of therapeutic effects of the thyme C.W, savory C.W. drops and thyme mixture in comparison with ranitidine - metoclopramide compound is the aim of this study. This is a randomized clinical trial study in 180 patients with dyspepsia selected in sequential sampling with similar diet, age group and the same smoking habit. They were randomly divided into four therapeutic groups; the whole groups except to the fourth group used thyme C.W, savory C.W. drops and thyme mixture C.W. with ten drops in three times a day during a month in a double blind method. The fourth group used ranitidine metoclopramide compound during a month with the following orders: 1- One tablet ranitidine every 12 hours 2- One tablet metoclopramide every 8 hours. It is necessary to be mentioned that biopsy urease test (BUT) and histology for evaluation of helicobacter pylori were performed in each group and each group was divided in two subgroups that include: HP. Positive and HP. Negative. This study indicated that C.W. drop, savory C.W. drop, thyme mixture drop and ranitidine - metoclopramide compound caused disappearance of 75% (or more)of symptoms of disease (the complete healing) in 55.6% , 53.3% , 42.2% and 42.2% of patients respectively. Thyme C.W, and savory C.W. drops had the similar therapeutic effects with that of ranitidine metoclopramide compound in the patients with functional dyspepsia. Thyme mixture C.W. had a similar therapeutic effect with ranitidine - metoclopramide compound. Urease positive patients gave more response especially with the thyme C.W. drop group.

To determine the distribution of lead in ambient air of Hamadan, 100 samples were taken in different places from December 1997 until June 1998. The places of samples collection, were divided to three locations in street (high traffic, medium traffic and low traffic), gas pump stations and parking of cars. Portable sampling pump and filter cellulose were used to obtain samples. The samples transferred to laboratory and analyzed with atomic absorption spectrophtometry. The results showed the concentration of lead was 1 μg/m3 in low traffic and 18 μg/m3 in high traffic places. The average concentration of lead in high traffic, medium traffic and low traffic were 7.99, 4.63, 3.80 μg/m3 respectively and have significant difference among concentration of lead in low traffic places with gas stations and parking of cars. The average concentrations of lead in ambient air of Hamadan was more than the standard limit (1.5 μg/m3) in ambient air recommended by World Health Organization (WHO), and United States Environment Protection Agency (USEPA).

Pain is one of the most irritant complication of the post tonsillectomy . In this study the effect of injection of 2% lidocaine at the end of operation for reduction of pain is evaluated. This is a clinical trial study. 60 children who were candidate for tonsillectomy were selected and randomly divided in to two groups. At the end of tonsillectomy 2% lidocaine was injected in to the tonsillar pillar in 30 patients (study group). Normal saline solution was injected in to the other 30 patients (control group). According to the results pain has been decreased significantly in 80% of the study group. This study revealed the effectiveness of this procedure for decreasing of the post tonsillectomy pain and cause the patients to awake smoothly without irritability.

One of the most common statistical tests in the medical journals is chi- square test. The present study compares the used chi-square tests in the medical journals with chi-square for trend. The statistical package of EPI6 was used to compare the methods. For some selected papers chi-square test and chi-square test for trend were used. The results showed in some tests although the chi-square test was statistically significant but the chi-square for trend was not significant and vice versus. It can be concluded when analyzing contingency tables, care should be taken for the appropriate test.

The aim of this study was determination of relative frequency of intestinal parasites in Hamadan military base in 1998.406 persons of residents were selected randomly and their stool samples were collected and related check lists were completed by referring to the doors. The samples were examined by formol-ether method. The detected results showed parasitic infection in 43.8% of residents with the maximum percentage associated with Ascaris (42.7%) and Giardia (21.9%). Age group of 31-40, primary school students and housewives had more infection rates. Also small families (<3) showed the lowest rate of infection. According to this fact that the source of providing vegetables for the military base and Hamadan city is the same, it seems that the sanitary standards are at higher levels in the base.  

One of the most impairment aspect in occupational health is the study of noise induced hearing loss (NIHL) in noise exposed workers. The study was carried out to find out relation and a model between noise exposed workers and NIHL in 1997. To determine NIHL in the worker in loom-650, 45 workers having no confounding factors were choosen. All the study population were examined using audiometer. Result showed the SPL range was 70-105 dBA. The average of work experience were 10.3 3.5 and age 37.4 6.7 years. Correlation coefficient between job history and NIHL in the left ear was 0.7099 and in the right ear was 0.7127. The Pearson's correlation coefficient between left and right ear was positive and equal to 0.69. The mean of NIHL between right and left ear was 14 dB which the regression model predicts the limit of hearing loss in left ear is 4.5 years and in right ear is 3.8 years. Although the results showed loss of hearing begins in right ear, but left ear had more hearing loss with increasing of experience years. The danger limit for hearing of these workers (based on 25 dB loss), for left ear and right ear were after 17 and 20.7 years of work experience respectively. To prevent serious impairment in the workers hearing, it is suggested to consider the limit of 17 year's occupancy in forging as a base for changing the occupancy.

Post operative Infection is the most common complication, that it is demonstrated by studies and morning reports in education sections. The most important composition way is preventive, that this isn't possible unless with recognition of the infection incidence method and transmission ways, therefore the study of operation room space, surgical device and patient body is important. This study is descriptive cross-sectional that 1085 cases prepared from operation room space, surgical device and patient body than it cultured in EMB and coccolate. 240 case was contaminated and the infection incidence rate was 22%, and the most abundance of contamination place was operation room (186 case equal to 77.5%). The most abundance of microbial was micrococcus and E.coli (150 case equal to 62.5%), bactries were sensitive to gentamicin and ciprofloxacin (72.8%) and were resistance to ampicillin and amoxicillin (75%). This study demonstrated the prevalence rate of infection in operation room in comparison to world standards (5%) were high.

Alpha-1-AntiTrypsin (α1-AT) is an inhibitory α1- Protease, and belongs to complex protein of glycoprotein type. From the activity point of view, it belongs to Seiren protease inhibitors (serpin). There are many reports in litreture concerning a decrease in the amount of α1-AT in patients with emphysema, skin disorders, adult liver disease, hypothyroidism, and so on. In hypothyroidic patients along with a decrease in the amount of T3, there is a significant decrease in the amount of α1-AT and consequently in the amount of TIC. Therefore, it can be expected that, in hyperthyroidic an increase in the amount of T3 results in an increase in the amounts of a1- AT and TIC. In this study, changes in TIC in hyperthyroidic patients in comparison with a control group was investigated. Measurements were performed on 72 samples, and by using T- test and determination of correlation coeffiecint, the above mentioned changes were analyzed. The results showed that TIC in hyperthyroidic patients (n= 42) had increased in comparison with the control group (n=30), (n=42, TIC=2.54 ± 0.414 mg/ml Vs n= 30, TIC= 1.87 ± 0.29 mg/ml). It was observed that in hyperthyroidic patients, there is a positive correlation between the amounts of T3 and TIC (r=0.71, p<0.0001). Therefore, it can be concluded that trypsin inhibitory capacity and α1-AT concentration had increased in hyperthyroidic patients.

Vater association is a congenital syndrome consisting of vetebral anomalies, imperforate anus, tracheo esophageal fistula and renal/radial abnormalities. In recent two decades, association of various other anomalies with this syndrome has been reported and extensive studies regarding its early diagnosis, management and prognosis have been under taken. In this paper in addition to the review of the preceding ten-year litrature, a female infant born in 1999 with this syndrome at the Fatemieh hospital and her successful surgical management has been reported.

Diffuse cutaneous mastocytosis is very rare variety mast-cell disorder which is called peseudoxanthomatous mastocytosis. Our case was a man who was eighteen years old. He suffered from yellow papules on the neck, extremities, axillary and groins. The appearance of large blisters following mild trauma or occuring spontaneously. Our patients Pruritus was not very server. The examination of his skin revealed yellow boggy and thickened skin with a doughy consistency without systemic involvement. Considering the clinical signs and using the skin biopsy reports of the patient, the illness was diagnosed as peseudoxanthomatous mastocytosis.

Hydrarthrosis refers to recurrent pattern of Joint effusions, usually of the knees, of long term, even life long duration. These recurrent attacks usually maintain a predictable preiodicity. In this rare case report we describe a patients with charactristic clinical manifestation that can be differentiated with initial symptoms of very common rheumatologic disorders such as R.A and sero negative spondyloarthropathy.