This study was performed to determine and compare the onset time of epidural anesthesia between lidocaine - sufentanil and lidocaine - bicarbonate.Eighty - one patients aged 14 - 65 years who underwent surgical procedures under epidural anesthesia were studied in the Hamadan Medical Sciences University Hospitals in 1998. This study was a double blind,clinical trial.The patients were divided randomly to three groups (lidocain-plasebo, lidocaine-sufentanil and lidocaine-bicarbonate). After performing the method , the obtained information were entered into the questionnaires. Next , all data were analysed by using one way analysis of variance in the statistical software EPI6.The cold sensory time (sympathetic block)in both groups of lidocaine-bicabonate and lidocaine - sufentanil (5.11min.) was shorter than that of the controlled group(10.22 min.). Besides, the pin prick loss time (sensory block) in the lidocaine- bicarbonate (7.92 min.) and lidocaine- sufentanil (7.29min.) groups was shorter than the controlled group (11.88 min.). Duration of analgesia in the lidocaine - sufentanile’s group was more than the lidocaine - bicarbonate’s and lidocaine - placebo's group (350.3 min.versus 221.5 min.and 160.6 min.).The three groups didn’t differ significantly with respect to systolic, diastolic and mean arterial pressure and heart rate. Among the narcotic complications, the incidences of pruritus was 3.7%, but other complications such as nausea, vomiting and respiratory depression were not observed.Consequently, sufentanil can be used in epidural anesthesia, because it has fast onset of the anesthesia, prolonged duration of analgesia and low incidence of its complications.