Economic globalization consists of four fields of production, investment and trade and finance globalization. These conditions, in a theoretical framework of complicated mutual dependency, explains the interwove interests of countries in the post-national, national and trans-national levels which includes governmental and non-governmental actors and consequently defines countries national interests a long with integration and correlation with other countries interests. In this regard, the main question of this article is that in terms of these conditions, what are the elements have to be considered in interaction with the international field, while it is to choose the resistant economy strategy in Iran? The result shows that the Islamic Republic of Iran, in order to realized the resistant economy in lesser cost, she has to emphasize on her strength points and relative and competitive priorities in interaction with world economy. In this case, the cost of sanctions and military threat towards Iran increases and the national interest and security of other countries take the same direction as Iran’s national interests and security. It is due to the fact that the country’s strategic weak points of economy remain safe of any threat.