Following the decline of Agh-Ghoyunlou in 907 AH, Esmaeil Shah (Sultan) Safavi took over the kingdom and chose Tabriz as the capital of his reign due to its superior political and economic situation. However, because of religious dogmatism, Ottoman attack, and Ghezelbash obstinacy, general conditions of Azarbayjan region fell apart. This challenging condition continued up to Shah Tahmasb period. In addition, due to his specific politics, the capital was changed from Tabriz to Ghazvin leading to gradual political and economic weakness of Azerbaijan. This critical condition motivated many statesmen, scientists, and experts of this area to immigrate for a number of reasons such as security and peace, freedom from dogmatism, scientific growth, earning power, money, and fame. Some were later sent from Azerbaijan and Tabriz to Russia and Contantinople by Ottoman while some others moved to Ghazvin and Isfahan in Iran. Separation from home weakened work and business forces in Azerbaijan resulting in a severe shock to the cultural and scientific bodies of this zone. This study aims to investigate the immigration reasons of Azerbayjan’s people to Isfahan and their occupations in the destination during Safavi age.