Although, the small and large industries are essentially different in the number of labor Force and the amount of capital, but their optimal production obviously is under the effect of productivity of labor Force. The aim of this study is to analyize and making clear the amount of the effectiveness of Factors on labor Force productivity in small and large industries in Iran during 1994 to 2013.Some of the important Factors that are effective in increasing productivity are: physical capital, human capital, the real wage level, the accumulation research and development (R & D), and the gap between actual and potential production. In this research, using the statistical information from the statistical center of Iran for the ninth industrial groups (I.S.C, Rev, 2) and using panel data method. The results showed that the impact of above Factors (except the gap production) on labor productivity is positive and the amount of them in small industries are more than the large ones. Thus, using the optimum of the studied variables in large industries and improving the performance of them cause the increase in labor production in small and large industries in Iran.