Introduction and objective: the interaction between man and nature makes a major portion of the human living, that due to the grave damages existing in this field, it needs to be renewed and effective approaches should be offered so that it can draw the interaction in a more sustainable and meaningful picture. One of the effective approaches is the mystical outlook of Rumi in Divan Kabir which underscores the principal position of man in the universe and connection with it. Another effective approach is a psychological approach toward nature. This paper attempts to study nature from psychological perspective and Rumi’ s mystical outlook in his Divan Kabir. Methodology: this study was conducted through search engines of the available databases such as Irandoc, Elsevier, Science direct, Pubmed, Google scholar, proquest, asha, and scopus, during the years 2222-2218 and 1382-1397 solar years, using the key words of nature, nature therapy, Rumi’ s mysticism, and Divan Kabir. Findings: utilizing nature in treatment centers as a solution to reduce environmental tensions, and enhancement of environmental quality has been appealing for a lot of researchers. The findings of the research prove that using greeneries and access to nature by users of treatment centers can provide a soothing atmosphere for both the staff and the patient. In addition, during the process of recovery of patients and reduction of the staff occupation tensions it is effective. In line with the research conducted concerning the the impact of nature on educational improvement and the soothing role of connection with nature over the body and soul of man, the study of the quality of the interaction with nature in educational centers appears to be necessary. The ongoing engagement and a great deal of education time at school and university make the atmosphere to play a significant role in the process of education, especially emotionally and emotion. Moreover, the research conducted show that among poets Rumi is known to be naturalist and, in his poetry, he has paid exclusive attention to the role of nature over the soul and psyche of man. Conclusion: use of nature in treatment centers, public offices, and private sectors is assumed to be an effective solution to reduce occupational and environmental tensions and promotion and job satisfaction. Nature therapy is one of the effective treatments in communicative skills disorder such as autism, anxiety disorders, stress, attention deficit and reduced concentration such as hyperactivity disorder, attention deficit, inattentiveness, and impulsivity. Furthermore, in mystical worldview of Rumi, man should accept nature in his inner self just like the emergence of divine attributes and names, and in the position of God’ s successor he should be a guardian. As a result, by understanding the special of man and the characteristics of man and nature correctly, the sympathetic relationship between him and nature was revealed in Divan Kabir from Rumi’ s outlook.