Due to increased interaction, speed of environmental changes and the complexity of relationships, the need for information, knowledge and awareness in organizational relationships and consequently scientific environment is felt. Defense and national security as country’s propellant, has been severely affected by scientific and technological development. Having a clear picture of the future, especially about the impacts of science and technology on defense and security environmental is complex. Meanwhile, defense and security organizations, according to their strategic nature, are highly dependent on various changes and trends in international, regional and national environment. These macro trends by interaction with each other and in the long term, lead to changes in country’s security and defense situation. This paper aims to determine the priorities of science and technology in the field of the country’s defense, national security and foreign policy which has been performed in several countries based on strategic studies, upstream policies, studying the trends of science and technology in the field of national security and along with comparative studies. And finally, the scientific and technological priorities affecting national defense and security environment is proposed.