Hygiene and cleanliness has always been of great importance in Islamic culture. Hygiene is not only observing the hygienic rules and to avoid personal contamination but also includes all aspects of human life and environmental contaminations. Therefore to avoid contamination which is considered as one of the major targets of environmental hygiene today has been considered as an obligation for a believer of Islam since decades. Though all these activities must be followed with prayer to god for the acts are done in remembrance of god to be accepted as pure worship. In this article, different Quran ayahs (Verses) and narratives relating personal and environmental hygiene are taken into consideration.Methods: Descriptive library survey has been collected and compiled using at hand resources including Quran, Tafseer, reliable books of Hadith, Behar-ol-Anwar, Nahj al-Balaghe, Qesal, Sahife sajadie, Osole Kafi, Majma'-al.Bayan and other existing publications. Results: Quran ayahs and all Hadith narrations regarding personal hygiene are presented separately for mouth & teeth, hair and nail, clothing and environmental hygiene, water, residence, garbage, nutrition and environment. The current discussion can play a very important and effective role in social actions in terms of renewal of religious thoughts, ideological and practical healthcare principles of the rich culture of Islam and can help to increase the level of awareness, healthcare trainings and to promote the health culture leading all cultural efforts.