Background and Aim: While stigma is discussed in psychiatry and psychology as a mental illness, it is hardly recognized by nurses. Stigmatization is a serious problem in all cultures and can have detrimental impacts on all spheres of life. The purpose of this analysis is to clarify the stigma of mental illness.Materials and Methods: In this study, we built on Walker and Avant’s (2005) model to do our analysis. After an extensive review of relevant literature, sources were excluded on the basis of the definition, functions, properties, premises, consequences and empirical referents.Results: Stigma is a powerful, widespread, permanent, social phenomenon which involves vulnerable populations. Stigmas coming from mental illnesses can result in discrimination, loss of social status, coping behavior, reduced quality of life, severe illness, substance abuse, lack of treatment and follow-up, and family turmoil.Conclusions: It is essential that nurses understand the comprehensive nature and components of mental illness stigmatization. By understanding stigmas, nursing practice can improve, and nurses would choose to care for every person individually.