Introduction: Proper learning strategies are a prerequisite for successful performance in alleducational environments. This study aims to investigate the use of various learning strategies inmedical students and its relationship with their academic performance. Methods: In this cross sectional study, data were collected from Medical students in ShirazUniversity of Medical Sciences. The statistical population of the study included all medical studentsstudying in the academic year 2016-2017 that 250 students were selected by simple randomsampling method. Data were collected through motivated strategies for learning questionnaire(MSLQ) which was developed by Printich et al (1993). In this study two learning strategies wereinvestigated; a meta-cognitive strategy including: planning, monitoring and regulating strategies (12items) and b) resources management strategies including: managing time and study environment (8items); peer learning (3 items) and help seeking (4 items). Validity and reliability of thequestionnaire were confirmed. Result: The results showed that the correlation between meta-cognitive learning strategies andresource management components (managing time and study environment, peer learning, helpseeking) with students’ academic performance were significant (P<0. 01). From which learningstrategies components, meta-cognitive strategies with β =0. 144 and managing time and studyenvironment with β =0. 277 could predict students’ academic performance. The results of ANOVAtest showed there there were no difference between students studying at different levels (basicsciences, clinical clerckship) in terms of various learning strategies. There was no significantdifference between male and female students in any of the learning strategies. Conclusion: The results of this study showed the importance of meta-cognitive and resourcemanagement strategies in predicting students' academic performance. Accordingly, the use of thesestrategies leads to increased learning in students.