Introduction: Hypertension is the third leading cause of death in the world. One of the ways to control chronic diseases is to increase patients' awareness, which requires improving their health literacy. For this purpose, in this study, a health literacy model for hypertensive patients in Shahid Rajaei Heart Hospital is presented. Methods: This research is applied in terms of purpose and in terms of survey method and a combination of qualitative and quantitative methods. The statistical population of the qualitative section is all experts in the field of health and treatment, and in the quantitative section the staff has a bachelor's degree or higher from Shahid Rajaei Heart Hospital. In the qualitative part, after conducting 23 theoretical saturation interviews, in the quantitative part of the research, 122 employees of Shahid Rajaei Heart Hospital were selected by counting method. In addition to library studies, the field method has been used through interviews in the qualitative section and questionnaires in the quantitative section. The validity of the questionnaire was confirmed by CVR and its reliability was confirmed by Cronbach's alpha. In order to analyze the data, open coding method in qualitative part and structural equations in quantitative part have been used. Results: The results showed that basic literacy with a coefficient of 0. 923, cognitive literacy with a coefficient of 0. 648, social literacy with a coefficient of 0. 585 and cultural literacy with a coefficient of 0. 483 are of great importance in the health literacy of hypertensive patients in Shahid Rajaei Hospital, respectively. Conclusion: Based on the findings of this study, it can be concluded that the existence of 4 basic literacy factors with reading and writing components and knowledge, cultural literacy with attitude components, values and norms, cognitive literacy with application components, evaluation, comprehension And access, and social literacy with components of communication and interaction can affect the health literacy of hypertensive patients.