The aim of this study was investigating the effect of 7 weeks of core stability and balance training on Motor function and Cognitive Failures in women with multiple sclerosis. For this purpose, 18 women with multiple sclerosis (Expanded Disability Status Scale 0-4.5, mean ± SD age; 36.66 ± 8.62 years) were selected based on the research entrance conditions with purposefully method and divided randomly to experimental and control groups (control group 10 persons and experimental group 8 persons). For evaluate Motor function, were used Timed 25 Foot Walking Test and Timed Up and Go Test. Too for evaluate Cognitive Failures was used Cognitive Failures Questionnaire, Then Experimental group conducted training for 7 weeks, 3 sessions in week, training consist of Core stability training with Swiss ball, Core stability training without Swiss ball and balance training. At that time, Control group didn’t conduct any sport training. For analyzing data used analysis of covariance.Result showed that after 7 weeks, Experimental group in Compare with Control group improved Motor function (P=0.002 for Timed 25-Foot Walking Test, P=0.001 for Timed Up and Go Test) and decreased total score of Cognitive Failures (P=0.001), scores of subscales like Distractibility (P=0.001), Memory (P=0.001) and Blunders problems (0.001) for Experimental group. So, core stability and balance training can be used for improvement Motor function and decreasing Cognitive Failures like Distractibility, Memory and Blunders problems in women with multiple sclerosis.