Introduction: Because of technology in health and treatment domain is changing rapidly; so, it is resulted that nurses increase and update their skills, continually. Since, one of the effective factors in job behavior is motivation; it is obvious that reorganization effective factors on motivation would be useful for nurses’ self – development behaviors.Aim: The aim of this study was assessing the relationship between the nurses’ self – development behavior, job motivation and factors influencing on their motivation.Method: This study was a descriptive-survey which (949) nurses who worked in hospitals in Tehran city were selected randomly in (2012). Cluster sampling was used with proportional allocation and Morgan method used for sample size estimating. For data gathering standards questioners were used; job motivation (London 1983), self-development behavior (Xu 2007), need for achievement (Williams& Hurtz 2009), self–efficacy, organizational and supervisor support (Maurer & et., al 2003).Their reliability were between (70%-80%). Data was analyzed by use of Path-Analyze through Lisrel 8.5 software.Results: There is a positive and direct relationship between the job motivation and factors such as need for achievement (b=0.24, t=2.47), self–efficacy (b=0.11, t=2.22), organizational support (b=0.19, t=2.31) and supervisory support (b=0.10, t=1.97). Moreover, there is a direct relationship between the nurses’ self–development behavior and factors self–efficacy (b=0.31, t=3.26), job motivation (β=0.64, t=3.89) and supervisor support (b=0.26, t=3.03). But there is no significant relationship (p>0.05) between their self–development behavior and factors need for achievement (b=0.15, t=1.74) and organizational support (b=0.05, t=0.64). Also, 44% changes in self development define with self efficacy, organizational and supervisor supports. So, the model had fitness.Conclusion: Self-efficacy, job motivation and supervisor support leads to improve nurses self-development behavior while need to chievement, self-efficacy, organizational support and supervisor support to provide motivation for self-development. managers and supervisors seem to provide the time, information, support, feedback, resources and rewards can play avital role in nurses learning and development.