Purpose: The aim of this study was to evaluate and compare topographic characteristics in bilateral keratoconus (KCN) patients with unilateral Vogt’ s striae. Methods: In this prospective cross-sectional contralateral eye study, the KCN patients that were enrolled in this study had a reliable diagnosis of bilateral clinical KCN with unilateral Vogt`s striae based on slit-lamp signs, as well as corneal topographic/tomographic maps. All the cases underwent a comprehensive ophthalmic examination, including uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), cycloplegic refraction (calculated by vectorial analysis), and placido disc-based Tomey topographer (TMS-4; Tomey, Germany). In this study, clinical and topographic characteristics of all cases were evaluated and compared between the contralateral KCN eyes with Vogt`s striae and those without Vogt`s striae. Paired sample t-test was used to compare the parameters with a normal distribution and the Wilcoxon signed rank test was used to compare the non-parametric parameters. P-value <0. 05 is statistically significant. Results: Fifty patients aged 20 to 38 years (27. 43± 5. 46) were recruited in this study. Our results showed that there were significant differences in sphere, cylinder, spherical equivalent, UDVA, CDVA and J0 (all p<0. 001) except for J45 (p=0. 58) between the contralateral eyes of KCN patients. In KCN eyes with Vogt’ s striae, flat (46. 48± 3. 33 vs 44. 44± 2. 22, p<0. 001), steep (52. 48± 4. 39 vs 47. 02± 3. 26, p<0. 001), minimum (46. 36± 3. 37 vs 44. 35± 2. 17, p<0. 001) and average keratometry (49. 27± 3. 96 vs 45. 74± 2. 60, P<0. 001) as well as Surface Regularity Index (1. 39± 1. 12 vs 0. 52± 0. 41, p<0. 001), Surface Asymmetry Index (2. 32± 1. 25 vs 1. 42± 1. 04, P<0. 001), Keratoconus Index (75. 07± 28. 83 vs 48. 01± 33. 52, p<0. 001) and Keratoconus Severity Index (65. 88± 22. 25 vs 38. 61± 29. 40, p<0. 001)were higher than the contralateral eye without Vogt’ s striae. Conclusion: Corneal topographic parameters showed a significant difference between the contralateral KCN eyes with and without Vogt’ s striae. These results should be noticed in clinical evaluations and treatments of KCN patients.