In this study we analyze the effective factors involved in drug addiction of women in jail of the central prison of Isfahan. This study is a qualitative study based on the ground theory analysis method in which thirty addicted women in the central prison of Isfahan were selected to study. The findings of the semi-structured interviews held showed that “the record of parental addiction”, “place of residence”, “life tensions”, and “relation with addicted friends” were the reasoning conditions; while “having children”, “economical-social position”, and “poor family relations” were the intervening conditions influenced the phenomenon of women drug consumption. Furthermore, the consequences arisen from this phenomenon for women have been “holding inferior jobs with low payment”, “committing social divergences”, in appropriate family relations”, and “punishment of prison”, each of which accompany its personal and social consequences.