Introduction: One of the most important factors that indicate hospital performance are hospital indicators. One of the fundamental developments and changes in the health system of Iran is the health system transformation plan, the effects of which should be examined from different aspects. The purpose of this research was to determine the performance indicators of hospitals affiliated to Zahedan University of Medical Sciences, Zahedan, Iran and compare them with the standards of the Ministry of Health, Treatment and Medical Education in 2019. Methods: This cross-sectional descriptive study was conducted in 2018 in public hospitals covered by Zahedan University of Medical Sciences. In this study, the most important performance indicators of the hospital from 2016 to 2019 were investigated in a targeted manner. The entry criterion was the completeness of the indicators information. In this study, to obtain accurate and reliable information, input data and output data were used as performance indicators. The data was analyzed using EXCEL software and descriptive tests. Result: In the present study, a total of 6 hospitals of Zahedan city under the coverage of Zahedan University of Medical Sciences were investigated. On average, 11, 200 people were hospitalized and 11, 003 people were discharged, which decreased to 11, 086 people hospitalized and 10, 450 people discharged after the transformation plan. The average number of emergency and outpatients was 71, 600 and 124, 571 respectively. Conclusion: The findings of the study showed that in terms of bed occupancy rate, the hospitals were in an average and poor condition compared to the standards of the Ministry of Health. But in terms of average hospitalization days, they were in an unfavorable situation. These results show that the transformation plan of the health system in this province has not yet reached its goals.