Introduction: People's tendency to risky behaviors is an important social issue that has affected the quality of life of people, social ties, human capital, and social health of communities. This study was to explain the influence of rural sociological factors on the tendency to high-risk behaviors using Durkheim anomie theories, Sutherland differential linkage, Park and Bridges ecology, Hershey social control, Alexander adaptation, Seaman social alienation, and Cohen subculture. Methods: The research method is survey type,the data were collected using a researcher-made questionnaire. The statistical population is all people over eighteen years old in the villages of Rudsar county based on the 2016 census were six thousand two hundred-five. The sample size was determined using Cochran's formula of four hundred people. The sampling method is cluster sampling. Results: The research findings showed that the average tendency of villagers to high-risk substance abuse behavior is lower than the hypothetical average. Conclusions: Inferential analysis of the hypotheses confirmed the influence of cultural, social, ecological, and individual factors on people's tendency to risky behaviors. By comparing regression coefficients, the variable of cultural factors has more effect than other variables on the villagers' tendency to high-risk behaviors.