Introduction: Any violent behavior, which is sex-dependent and results in physical, sexual, psychological injuries and women suffering, is regarded as spouse abuse. It has adverse social and familial consequences.Current study was aimed to assess factors affecting spouse abuse in women in Shiraz city.Methods: This cross-sectional descriptive and analytic study was conducted, by simple random sampling, on 197 women victims of spouse abuse referred to the Shiraz legal medicine center in 2013. The data were collected using demographic information form and standard questionnaires of assessing violence against women, general health, and sexual function. Data analysis was performed by SPSS version 18 statistical software using, Pearson’s correlation test and multiple regression.Results: Among the studied people, the highest rate of spouse abuse was for psychological violence, with an average of (55.80), and the lowest for economic violence, with an average of (6.11). There was a significant and direct correlation between dimensions of physical violence (P=0.001; r: 0.10), economic violence (P=0.007; r: 0.15) and general violence (P=0.052; r: 0.11) and the general sexual function. Moreover, the variables of contraception, spouse family involvement, history of husband addiction, number of children, economic class of spouses’ parents, spouse age and general sexual function significantly predicted the spouse abuse in women (P<0.05).Conclusion: In regards to the consequences of spouse abuse and its association with the couple’s characteristics, increasing the required awareness in the field of the solving such problems and the factors influencing it, seems to be crucial.