Aim: This study aimed to analyze the effects of spiritual–religious treatments on some public health variables (e. g. , quality of life, anxiety, and depression) through a meta-analysis.Method: A meta-analysis was conducted in this study. The statistical population included the studies regarding the effects of spiritual–religious treatments on some public health variables (e. g. , quality of life, anxiety, and depression). Finally, 17 studies that met the methodological inclusion criteria for this meta-analysis were selected as the research sample. Based on the exclusion criteria, the other studies were then excluded. Moreover, a meta-analysis checklist was employed to comply with the inclusion criteria and extract relevant data of each study. In the end, fixed and random effect size values were reported.Findings: According to the research findings, spiritual–religious treatments had significant effects on quality of life, anxiety, and depression at 0. 001. Furthermore, the composite effect size values of these three variables were 2. 41, -3. 76, and -2. 05, respectively (based on the standard error of the mean). Hence, the effect size values of these variables were evaluated high with respect to Cohen’s D.Conclusion: The results of this meta-analysis indicated the significant effects of spiritual–religious treatments on quality of life, anxiety, and depression. Findings were explained based on psychological foundation and clinical considerations were discussed.