Mental health is an inner and satisfying feeling combined with constructive communication and a transcendent existence in a specific cultural framework that leads to making life and death meaningful. Based on his original theory and the physicality and spirituality in the soul, he considers the soul a complete and changing order of existence with dynamic movement. According to the soul's originality, man's truth depends on the circumstances of the soul. Physical behavior, whether good or bad, is the result of the activities and powers of the soul in the levels of feeling, imagination, and reasoning. Mulla Sadra believes from such an approach that, first of all, mental health and spiritual health are necessary. Secondly, due to the guiding nature of the soul and that the external and internal powers are under the nobility of the intellectual powers, he achieves the two indicators of science and acts according to their quality in terms of spiritual value and perseverance in continuity and repetition as necessary for self-health. The present research focused on the indicators of spiritual health in an analytical-descriptive way. It concluded that spiritual health depends on the effort of a person to acquire proper knowledge, especially self-knowledge, knowledge of God, and knowledge of the eternal truths of the hereafter. Despite all the emphasis on the value of action and its interaction with the soul, conditions, especially human sciences and consciousnesses, have a higher rank than actions due to their union with the soul.