Fatty liver disease is a type of fatty accumulation in liver cells that, if not controlled, leads to a malignant process of fibrosis of the liver and its cellular destruction. In this study, the effects of endurance, resistance and combination exercises on liver enzymes in ovariectomized rats were investigated. For this purpose, 50 Wistar rats were kept under controlled conditions (temperature, light and dark cycle and free access to food and water) and after randomization with exercise protocol, randomly divided into 5 groups of 10 per group.: Sham, ovariectomy (OVX), ovariectomized and resistance training group (OVX + RE), ovariectomized and endurance training (OVX + EN), ovariectomy and combined endurance-resistance training (OVX + EN) + RE). 48 hours after the end of the last session rats were anesthetized and sacrificed. Statistical analysis was performed using one-way ANOVA and Tukey post hoc test (p <0. 05). The results showed that endurance and resistance training and combination had significant effect on ALT and AST liver enzymes in uricectomized rats (p <0. 05). But combined exercise had the most effect on ALT and AST hepatic enzyme in uricectomized rats (p <0. 05). Ovariectomy increased ALT and AST liver enzymes (p <0. 05). Six weeks of endurance and resistance training alone and in combination improved ALT and AST hepatic enzymes (p <0. 05) but the combined effect of these two interventions was stronger (p <0. 05). The results of the present study showed that the combination of endurance-resistance training has more protective power than any alone in changes in menopause in liver tissue. Therefore, possibly improving lifestyle by combining appropriate endurance-resistance exercises can prevent many potential disorders during menopause.