Comparison of the effect of 10 weeks of high intensity interval training with continuous endurance training on miR-205 and VEGF gene expression in mice with breast cancer

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Rezaei Ziba; SHAKERIAN SAEID; NIKBAKHT MASOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF APPLIED HEALTH STUDIES IN SPORT PHYSIOLOGY Year:2019 | Volume:6 | Issue:1 Page(s): 37-44

Download Full-Text

Persian Verion

View:

344

Download:

Cites:

Information Journal Paper

Title

Comparison of the effect of 10 weeks of high intensity interval training with continuous endurance training on miR-205 and VEGF gene expression in mice with breast cancer

Author(s)

Rezaei Ziba | SHAKERIAN SAEID | NIKBAKHT MASOUD | Issue Writer Certificate

Keywords

Breast cancer

HIIT

Mir-205

Vascular Endothelial Growth Factor

Abstract

Many genes are involved in the development of Breast cancer. One is the VEGF (Vascular Endothelial Growth Factor) gene, one of the most important angiogenesis factors. On the other hand, one of the suppressive microRNAs is Mir-205, which is significantly less translatable in breast tumors compared to healthy matched tissue. Therefore, in this study, we compared the effect of 10 weeks of high intensity periodic training with continuous endurance training on Mir-205 and the VEGF gene in mice with Breast cancer. The study was performed on 18 Balbci mice, with a mean body mass of 18-20g. The estrogen-dependent MC4-L2 carcinoma cell line was cultured, cultured, and then one million subcutaneous cancer cells were injected into the herb. One week after tumor formation, mice were randomly divided into three groups of 6: Control (C). ), Continuous endurance (E) and interval high intensity (H) were divided. Exercises were performed 5 times a week for 10 weeks. Each session of protocol E was 60-65% vo2max and group H was 90-85% vo2max. Expression of Mir-205 and VEGF was measured by Realtime PCR. . The expression level of Mir-205 was significantly in high intensity Interval group (p = 0. 000), and in the Continuous endurance group (p = 0. 001), than in the control group. The VEGF gene expression was significantly decreased in the in high intensity Interval group (p = 0. 003) and in the Continuous endurance group (p = 0. 005). Given the incremental effect of in high intensity Interval training and continuous endurance on Mir-205 expression and a decreasing effect on VEGF gene expression in mice with Breast cancer, these two types of training may be effective in decreasing tumor growth. Also, according to the results, High intensity interval training due to less time, may be more effective.

Cites

No record.

References

No record.

Cite

APA: Copy

Rezaei, Ziba, SHAKERIAN, SAEID, & NIKBAKHT, MASOUD. (2019). Comparison of the effect of 10 weeks of high intensity interval training with continuous endurance training on miR-205 and VEGF gene expression in mice with breast cancer. JOURNAL OF APPLIED HEALTH STUDIES IN SPORT PHYSIOLOGY, 6(1 ), 37-44. SID. https://sid.ir/paper/269323/en

Vancouver: Copy

Rezaei Ziba, SHAKERIAN SAEID, NIKBAKHT MASOUD. Comparison of the effect of 10 weeks of high intensity interval training with continuous endurance training on miR-205 and VEGF gene expression in mice with breast cancer. JOURNAL OF APPLIED HEALTH STUDIES IN SPORT PHYSIOLOGY[Internet]. 2019;6(1 ):37-44. Available from: https://sid.ir/paper/269323/en

IEEE: Copy

Ziba Rezaei, SAEID SHAKERIAN, and MASOUD NIKBAKHT, “Comparison of the effect of 10 weeks of high intensity interval training with continuous endurance training on miR-205 and VEGF gene expression in mice with breast cancer,” JOURNAL OF APPLIED HEALTH STUDIES IN SPORT PHYSIOLOGY, vol. 6, no. 1 , pp. 37–44, 2019, [Online]. Available: https://sid.ir/paper/269323/en

Related Journal Papers