Avicenna Journal of Neuropsychophysiology
Year:2014 | Volume:1 | Issue:1|Papers Count:8

Background: Tramadol is an opioid analgesic indicated for the treatment of moderate and severe pains. In the case of long administration, tramadol has a potential to cause dependency, tolerance and drug abuse.Objectives: This study aimed to investigate the prevalence and factors associated with tramadol abuse among college students based on the Theory of Planned Behavior (TPB) as a theoretical framework.Patients and Methods: This descriptive-analytical study was performed on 400 college students of Hamadan universities recruited with a stratified sampling method. The data-gathering tool was a questionnaire based on the TPB constructs. Data was analyzed by logistic regression and bivariate correlations using SPSS-19 software.Results: The subjects reported 50%, 35% and 77% of maximum receivable scores of attitude, subjective norm and perceived behavior control, respectively. In total, 12.5% of participants indicated drug abuse in the past. Subjective norms and perceived behavioral control were better predictors for tramadol abuse.Conclusions: Results demonstrated the unique importance of subjective norms and perceived behavioral control when examining substance abuse among college students.

Background: Drug addiction is a drastic problem in women’s life which is growing rapidly and has attracted a lot of attention in Iran’s academic community who investigate addiction. Process of addiction in women highly differs with men, moreover, individual, familial and social consequences of addiction for women are much more intense than that of the men.Objectives: This study aimed at achieve a holistic view on the onset of drug addiction and factors related to the continuation of drug abuse in female drug addicts in Hamadan province, Iran.Materials and Methods: Fifty nine addicted women who were admitted to the only rehabilitation and treatment center for addicted women in Hamadan and volunteered to participate in this cross-sectional survey were chosen. Following clinical interviewing and completing the health questionnaire, they were asked to fill up a standard questionnaire to obtain demographic information including complete and comprehensive questions about sociodemographic and familial states which were effective in onset, continuation and cession of drug abuse.Results: The most common drug used by 48 women (81.35%) was th eopium, followed by crack (8.47%), heroin (1.69%), methadone (1.69%)and cannabis (1.69%). Mean age of the first time experience of cigarette smoking was 17.11±9.22 years. Also, the mean age of the first time drug substance use was 27.62±10.46 years and the mean duration of drug use was 5.2±12.0 years. Among studied women, 74.57% used drugs on a regular basis. General Health Questionnaire results indicated that 74.6% of the studied women had suboptimal general health. Twenty six women (44.6%) were referred to a psychologist or psychiatrist. The main reason for referring to a psychologist or psychiatrist was addiction withdrawal in 19.35%, depression and anxiety in 5.06%, and familial problems in 12.9% and headache in 9.68%. Among the examined individuals, 50.8% had once decided to quit, 23.7% for two times, 11.9% for three times, 8.5% for four times and 1.7% for sixteen times.Conclusions: Significant differences are expected regarding the various patterns of onset, continuation and cession of drug abuse between the women and men. There are also different incentives for participation of women in the treatment processes which is dependent on the country's social and cultural features.

Ecstasy or 3, 4-methylenedioxymethamphetamine (MDMA), is a synthetic amphetamine derivative and an illicit drug of abuse which is primarily consumed by young people in dance and music environments. Generally, MDMA causes elevated mood and a heightened sense of empathy. It is capable of producing both reversible and irreversible brain changes, such as expression of microglia cells, hypertrophy of astrocytes and neuronal degeneration in various areas of the brain. It has been reported that degenerating pyramidal and non-pyramidal neurons are localized within the parietal cortex, teniatecta and thalamic nuclei. MDMA can also result in degenerating neurons in the insular and perirhinal cortex. The neurotoxicity associated with MDMA exposure may be the result of oxidative stress leading to the formation of hydroxyl radicals, lipid peroxidation and an increase in the number of tunnel positive cells in the hippocampus. The imbalance between reactive oxygen species (ROS) and the internal antioxidants result in oxidative stress. Oxidative stress is generated by an imbalance between reactive oxygen species (ROS) and antioxidants and may contribute to the neurotoxicity of MDMA in the brain. 3, 4-methylenedioxymethamphetamine (MDMA) or ecstasy has excitatory effects on the central nervous system as an amphetamine derivate, particularly on hippocampus, neostriatum and cerebellum. MDMA has excitatory effects on the central nervous system, mostly on the serotonergic, dopaminergic and noradrenergic synaptic endings. The highest affinity is noted for serotonin transporter (SERT) and 5-hydroxytryptamine 2 (5-HT2) receptors.

Background: Anxiety is a physiological state characterized by cognitive, somatic, emotional, and behavioral components. There is some evidence in traditional medicine for the effectiveness of lettuce (Lactuca sativa) in the treatment of anxiety in humans.Objectives: The present study investigated the effects of a hydro-alcoholic extract of lettuce on rat behavior in the elevated plus-maze (EPM) and the results compared with the effects of diazepam.Materials and Methods: Adult male Wistar rats weighing 200 – 240 g were used in the present study. Seven different groups of rats received an intraperitoneal (IP) injection of lettuce extract (50, 100, 200 mg/kg), diazepam (0.3, 0.6, or 1.2 mg/kg), or vehicle (control group), 30 minutes before entering the EPM test. The total distance covered by the animals, the percentage of entries into the open arms of the EPM, the time spent in the open arms, and the number of entries into the closed arms were recorded for a 5 minutes duration.Results: An IP injection of both diazepam and lettuce extract before an EPM trial significantly increased the percentage of open arm entries and the time spent in the open arms. Diazepam decreased the total distance covered by the animals and the number of closed arm entries, whereas lettuce extract had no effect on these parameters. Locomotor activity was not significantly changed by the lettuce extract.Conclusions: Acute administration of lettuce extract has an anxiolytic profile in rats similar to that of anxiolytic diazepam at low dose. Future investigations are essential for better understanding of the anxiolytic properties and neurobiological mechanisms of lettuce extract.

Background: Sildenafil (Viagra) has been introduced to treat erectile dysfunction by acting as phosphodiesterase 5 inhibitor and hence accumulation of guanosine cyclic monophosphate (cGMP). On the other hands, the nitric oxide/cGMP signaling pathway has crucial role in synaptic plasticity processes like long-term potentiation (LTP) in the central nervous system considered as a model of learning and memory.Objectives: The aim of the present study was to determine the effects of sildenafil on different stages of spatial learning and memory of rat using radial maze.Materials and Methods: The effects of pre-training, pre-retrieval oral administration or post-training i.p. injection of sildenafil (10 mg/kg) in radial maze task were investigated.Results: Pre-training and post-training administration of sildenafil impaired radial maze task. Pre-retrieval injection of sildenafil decreased reference memory and working memory errors. Therefore, sildenafil impaired acquisition and consolidation of spatial learning and memory but improved retrieval of spatial memory in radial maze.Conclusions: Sildenafil has differential effects on the spatial learning and memory processing. It seems this result is due to accumulation of cGMP in the neural structures related to learning and memory processing. As different neural structures are involved in different learning and memory tasks, these results might be due to the different actions of cGMP in different structures of brain.

Welcome to the first issue of Avicenna journal of neuropsychophysiology. Publishing this journal was one of the first wishes and ambitions of us in this university, which by God's will and efforts of editorial board has been achieved.Improvement in science generally occurs in its borders and researchers who work interdisciplinary play an effective role in its betterment and efficiency. To provide suitable relation between basic and clinical sciences which is necessary, we have made up our mind to publish such journal to meet this goal.

Introduction: Many conditions can mimic psychiatric symptoms. Amongst them, intracranial mass and space occupying lesions have a significant importance. Aggression and hallucination are seen in association with a basal frontal lesion, and may mimic psychotic syndromes.Case Presentation: A 37-year-old man with no previous mental illness presented with a month history of headache, blurred vision, diplopia, aggression, loss of interest, fatigue, insomnia, and depressed mood. He was suffering from daily auditory hallucination which described as musical hallucination lasting about an hour per day. The headache was tension-type which appeared swinging, two times per week lasting 30 minutes. After auditory hallucination, the patient disclosed nausea, vomiting, and transient loss of consciousness. He referred from a neurologist, because, conventional therapy for the patient had not response. There were no other neurological symptoms or deficits. The results of neurologic examination including evaluation of the cranial nerves as well as head and neck examination were normal, But, psychiatric symptoms developed. Therefore, he was admitted to the psychiatric ward. The patient was diagnosed with major depressive disorder (MDD) with psychotic feature by Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria and received psychiatric treatment. He started on antipsychotic agent (olanzapine 5 mg tablet/bid), antidepressant (sertraline 50 mg tablet/qhs) and valproate sodium 200 mg tablet/bid for treatment of aggression and headaches. After five days of admission, primary symptoms of headache and auditory hallucination were better but diplopia and blurred vision were still present. Ophthalmology examination revealed. The pupils were round, isochoric, and normoreactive to light and accommodation, and there was no sign of a relative afferent pupillary defect. Ophthalmoscopy showed a papilledema in both eyes. In order to rule out the intracranial pressure and their causes, neuroimaging was requested. An emergent noncontrast-enhanced computed tomography (CT) image of the head revealed a hyperdense mass in midfrontal convexity. Magnetic resonance imaging of the brain and orbits with and without intravenous gadolinium enhancement further delineated the CT findings and highlighted a large avidly enhancing midline mass within the frontal region measuring approximately 48×50×42 mm in axial dimension, consistent with a meningioma. The patient discharged from psychiatric ward with necessary advices and was admitted to the neurosurgery ward for further evaluation. A first psychosis episode is a clinical condition with principal indication for cerebral CT-scan.Discussion: Meningioma is a common intracranial tumor with a variety of histomorphologic growth patterns, which are usually easily recognized. The three most common symptoms are headaches, mental status changes, and paresis. Aggression and hallucination are seen in association with a basal frontal lesion and may mimic psychotic syndromes like hypomania and schizophrenia. A first psychosis episode is a clinical condition with principal indication for cerebral CT-scan.

Background: Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid b-peptide (Ab) has a pivotal role in the pathogenesis of AD.Objectives: Given the contradictory results of Ab (25-35) on the memory, in the present study we have examined the effect of Ab - induced memory impairment.Materials and Methods: Wistar male rats received an intrahippocampal (IHP) injection of Ab (25-35).The learning function in the rats was examined by the passive avoidance task.Results: The results showed that Ab (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task.Conclusions: These data suggest that single bilateral microinjection of Ab (25-35) could impair memory and can be used as an AD model in Wistar rats.