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Information Journal Paper

Title

EFFECT OF AMYLOID β-PEPTIDE ON PASSIVE AVOIDANCE LEARNING IN RATS: A BEHAVIORAL STUDY

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  0-0

Abstract

 Background: ALZHEIMER'S DISEASE (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid b-peptide (Ab) has a pivotal role in the pathogenesis of AD.Objectives: Given the contradictory results of Ab (25-35) on the memory, in the present study we have examined the effect of Ab - induced memory impairment.Materials and Methods: Wistar male RATS received an intrahippocampal (IHP) injection of Ab (25-35).The LEARNING function in the RATS was examined by the passive avoidance task.Results: The results showed that Ab (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task.Conclusions: These data suggest that single bilateral microinjection of Ab (25-35) could impair memory and can be used as an AD model in Wistar RATS.

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    APA: Copy

    NIKKHAH, ALI, GHAHREMANITAMADON, FATEMEH, ZARGOOSHNIA, SOMAYEH, SHAHIDI, SIAMAK, & SOLEIMANI ASL, SARA. (2014). EFFECT OF AMYLOID β-PEPTIDE ON PASSIVE AVOIDANCE LEARNING IN RATS: A BEHAVIORAL STUDY. AVICENNA JOURNAL OF NEURO PSYCHO PHYSIOLOGY, 1(1), 0-0. SID. https://sid.ir/paper/345212/en

    Vancouver: Copy

    NIKKHAH ALI, GHAHREMANITAMADON FATEMEH, ZARGOOSHNIA SOMAYEH, SHAHIDI SIAMAK, SOLEIMANI ASL SARA. EFFECT OF AMYLOID β-PEPTIDE ON PASSIVE AVOIDANCE LEARNING IN RATS: A BEHAVIORAL STUDY. AVICENNA JOURNAL OF NEURO PSYCHO PHYSIOLOGY[Internet]. 2014;1(1):0-0. Available from: https://sid.ir/paper/345212/en

    IEEE: Copy

    ALI NIKKHAH, FATEMEH GHAHREMANITAMADON, SOMAYEH ZARGOOSHNIA, SIAMAK SHAHIDI, and SARA SOLEIMANI ASL, “EFFECT OF AMYLOID β-PEPTIDE ON PASSIVE AVOIDANCE LEARNING IN RATS: A BEHAVIORAL STUDY,” AVICENNA JOURNAL OF NEURO PSYCHO PHYSIOLOGY, vol. 1, no. 1, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/345212/en

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