The aim of this study is to investigate the effect of foliar application of Acadian seaweed extract and Biomix liquid poultry manure on vegetative growth, corm, and yield of saffron. The experiment was conducted in a randomized complete block design with three replications in the city of Ferdows city during the 2017-2018 growing year. Experimental treatments included four levels of Acadian seaweed extract (0, 1, 1. 5, and 2 kg. l000 L-1 water) and four levels of liquid Biomix liquid poultry manure (0, 4, 5, and 6 L. l000 L-1 water). The results showed a significant effect of treatments on the studied traits, such as maximum number of flowers (99. 50 N. m-2), fresh yield of flowers (33. 34 g. m-2), dry weight of saffron stigma (0. 341 g. m-2), dry leaf weight (0. 592 g plant-1), and leaf length (63. 75 cm) obtained in 2 kg. l000 L-1 seaweed extract. Besides, the results showed a significant effect of liquid poultry manure on flower number and yield (94. 250 N. m-2 and 32. 285 g. m-2, respectively), leaf length (60. 66 cm), fresh and dry leaf weight (0. 74 and 0. 46 g. m-2, respectively), and total weight of replacement corm (37. 02 g. m-2). Also, the least amount of the mentioned traits were observed from the control treatment. The interaction between these two fertilizers was also significant in fresh and dry leaf weight and the total and average diameter of replacement corm. Thus, fresh and dry leaf weight (210% and 273%, respectively) were highest in the treatment of 2 kg. l000 L-1 of seaweed extract and 6 L. l000 L-1 of liquid poultry manure. Moreover, total and average diameter of replacement corm (33% and 50%, respectively) were highest in the treatment of 2 kg. l000 L-1 of seaweed extract and no liquid poultry manure. According to the results of this study, the use of Acadian seaweed extract (2 kg. l000L-1 water) alone or in combination with Biomix liquid poultry manure (6 L. l000 L-1 water) can play an important role in enhancing the vegetative growth, corm, and yield of saffron.