Background: Maintaining health, as one of the main and old concerns of mankind, is influenced by various factors. Therefore, global health-related declarations and strategies emphasize proper drug provision and consumption, as well as effective treatments. Self-medication, a controversial health issue, is three times commoner in Iran than the world average record which makes the country stand the second in Asia. Investigating the causes of self-medication based on the Health Belief Model (HBM) is a scientific and effective method to control the problem. Thus, this study attempted to identify and rank the factors associated with self-medication.Methods: In this cross-sectional descriptive-analytic study, 380 elderly adults were selected based on stratified random sampling with proper ratios. The data were collected through structured interviews using a 47-item questionnaire which covered the HBM subsections. The validity and reliability of the questionnaire were confirmed. The data were analyzed through SPSS16.Findings: The age average of the participants was 66±5.31. Moreover, 36.10% of the subjects were retired, 29.40% had an education of primary school level, 53.90% were under the support of social insurance, 77.60% consumed over-the-counter drugs, 85.30% kept drugs at home, 42.30% took sedative drugs, and 15.10% consumed psychiatric drugs. The score for perceived sensitivity and barriers were 50.21 and 70.23, respectively.Self-medication was found to be significantly related with gender, marital status, and education level. In addition, a successful previous experience of self-medication and considering drugs as harmless were suggested as the main causes of self-medication. Furthermore, mass media were discovered to be the most effective solution to prevent self-medication.Conclusion: In this study, the prevalence of self-medication was high and the alterable factors were in undesirable conditions. Although the subjects did not show a minimum score of 50% in different subsections of HBM, the self-efficacy average was desirable which could lead a false sense of confidence and increased self-medication.