The current study was conducted to evaluate the efficacy of Thymbra spicata (TS) and Echinacea purpurea (EP) powders on quality of breast muscle in broiler chickens exposed to Campylobacter jejuni. A total of 192 one-d-old straight-run broiler chicks (Ross 308) were randomly allocated to 6 dietary treatments in a completely randomized design with 4 replicates and 8 birds per each. The experimental diets were as follows: 1) basal diet without additive (control group); 2, 3) basal diet supplemented with EP powder (0. 25 and 0. 50%; EP-0. 25 and EP-0. 50); 4, 5) basal diet supplemented with TS powder (0. 25 and 0. 50%; TS-0. 25 and TS-0. 50), and 6) basal diet supplemented with Erythromycin (55 ppm). All of the broiler chicks were orally gavaged with Campylobacter jejuni (4×10 11 cfu/mL) on d 21. Malondialdehyde concentration in breast muscle was significantly decreased by supplementing diets with EP-0. 25, TS-0. 25, and erythromycin (P<0. 05). All experimental treatments also resulted in a significant decrease in the colonization of psychrophilic bacteria in breast muscle when compared with the control group (P<0. 05), however, aerobic bacteria count was significantly decreased only by TS-0. 25 and erythromycin (P<0. 05). Other traits such as pH, color, chemical composition, water holding capacity, drip loss, cooking loss, and press loss were not significantly affected by treatments. As a conclusion, for the prevention of lipids peroxidation and the decline of psychrophilic bacteria count, it could be advised to use EP and TS with 0. 25% diet instead of erythromycin, however, TS is preferable to EP, because of the higher antibacterial activity on reduction of aerobic bacteria count.