Introduction: This study aimed to determine the effectiveness of trauma-focused cognitive behavioral therapy (TF-CBT) to improving the symptoms of PTSD in 2 sexually abused children. Method: This research conducted with a single-subject design using multiple baselines and follow-up paradigm. The statistical population consisted of all 9-12 years old children with sexual abuse experiences referred to the Center of Clinical Tests of Forensic Medicine in 2016. By a urposeful sampling method 2 children were selected and undergon the TF-CBT therapy. Children were responded to the Child Post-traumatic Symptom Scale (CPSS), and The Parent Report of Post-traumatic Symptoms (PROPS) instruments completed in the baseline, 4, 8, 12 and16th sessions of intervention, and in 1, 2 and 3rd months fter intervention, as well as, in 1st and 2nd years after interventions. Data was extracted from instruments and analysed by visual charts, percentage of recovery, Effect size and PND analysis. Results: Results were shown that TF-CBT could significantly improve the PTSD symptoms in sexually abused children after interventions and therapeutic effects were stable in follow up. Conclusion: It could be concluded that TF-CBT is effectively improving symptoms of PTSD in sexually abused children and vulnerable children need specialists.