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Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    2-7
Measures: 
  • Citations: 

    0
  • Views: 

    2161
  • Downloads: 

    0
Abstract: 

Background and purpose: Mortality rate from gastric cancer is growing in the world.Nowadays, in many cancers, between cancer development and changes in EGF receptor expression levels there is a very precise relationship. Perhaps one of the best known of these changes in gastric cancer is over expression of Her1 & 2 receptors. This study investigated the expression rate of these two receptors in gastric locally advanced adenocarcinoma, and its correlation with survival of patients.Materials and methods: The samples include 130 paraffin blocks of patients with gastric cancer in Imam Khomeini Hospital in Sari 1383-88.4 micron sections of tissue blocks were prepared and placed on slides. Then slides were deparaffinized with xylene and dehydrated using alcohol. The endogenous peroxidase activity was inhibited. Her2 Antibody is located on them. Finally, they were stained with hematoxylin.Results: Her1 marker only in 23 samples (17.6 %) and Her2 marker only in 20 samples (15.4 %) were positive. Accompanying these two markers in 9 patients (6.9 %) was also seen simultaneously. The survey marker Her2 based on sex revealed in 91 male patients, only in 11 cases (11.6 %) and in 39 women only 9 cases (23 %) were positive Conclusion: Expression levels of Her1 marker increased with increasing disease stage. These findings may indicate the diagnostic value of this marker in patients with gastric adenocarcinoma.Probably, the rate of HER1 and HER2 receptors expression is associated with invasion and survival of patients.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    9-17
Measures: 
  • Citations: 

    0
  • Views: 

    1379
  • Downloads: 

    0
Abstract: 

Background and purpose: Penicilliums have high diversity among fungi species and some of them are found to be very useful. Some studies have evaluated their antimicrobial and cytotoxic effects.Penicillium citrinum is a genus of the penicilliums that produces mycotoxin citrinin. Therefore, it is worthy to assess its cytotoxic effect.Materials and methods: The DNA of the fungus obtained from the soil samples from the campus of Mazandaran University of Medical sciences was extracted. Then DNA sequencing was done and the ethanolic extract including metabolites was taken out. The effect of different concentrations of test solution were evaluated on cancer cell lines of human liver (HepG2), lung (A549), ovary (SKOV3), and breast (MCF7) and also on kidney (LLCPK1) and ovary of Hamster (CHO) normal cell lines using MTT method. Cisplatin was considered as positive control. The data was analyzed using Prism Ver.3, ANOVA and t-test.Results: The findings revealed significant differences between the levels of IC50 of fungus metabolites and cisplatin in all cell lines (P<0.005). Also, the level of IC50 of fungus metabolites on normal cell lines was significantly different from that of the cancer cell lines (P<0.05).Conclusion: This study showed that ethanolic extract of P. citrinum metabolites did not have a considerable toxicity effect on cancer and normal cell lines. However, it increaesd the inhibitory effect of cancer cell proliferation.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    19-28
Measures: 
  • Citations: 

    4
  • Views: 

    942
  • Downloads: 

    0
Abstract: 

Background and purpose: Hypertension is a common, chronic and relapsing disease that is considered as a challenging and most important in terms of health throughout the world due to the extensive and long-term changes in behavior related to lifestyle. The aim of this study was to assess the effect of self-management program on self- efficacy in hypertensive patientsMaterials and methods: This research is a quasi-experimental study in 150 patient with mildto- moderate primary Hypertension referred to health centers affiliated to Tehran University of Medical Sciences is were randomly assigned in two experimental (75) and control (75) groups. The intervention consisted of a four-hour one-day workshop and the project scenario and then had two months of telephone follow up. Data was analyzed using SPSS-16 Software and descriptive and analytical statistical.Results: The results showed, the rate of self-efficacy after of the intervention, there are significant differences between experimental and control group (P=0.000), Self-management program has been able to increase patients' level of self-efficacy.Conclusion: Self-management program and subsequent programs, promoting of self-efficacy, Can be done to persuade patients to behavioral changes, adherence to diet, medication, exercise and physical activity. As a result, is convenient and efficient in blood pressure control.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    30-35
Measures: 
  • Citations: 

    0
  • Views: 

    794
  • Downloads: 

    0
Abstract: 

Background and purpose: Insulin regulates cell growth and apoptosis by binding to its receptor (INSR).Many studies show that variation in Insulin pathway play a plausible role in the development of CRC. The goal of this study is to evaluate incidence of Insulin Receptor (INSR rs1799817) in Iranian and to investigate the role of this polymorphism in increased risk to CRC.Materials and methods: genotyping of the Insulin Receptor (INSR rs1799817) were determined in a series of 110 colorectal cancer patients and 110 controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR-RFLP). We use SPSS (V16) for statistical analysis in order to investigate relationship between genotypes and risk of CRC.Results: Results show that polymorphism INSR rs 1799817 is not a predisposing factor to increased risk to CRC (P=0.49). Incidence of mutant allele between patients and controls didn't show significant difference (OR=1.12 95% CI=0.73-1.69).Conclusion: These findings suggest that polymorphism Insulin receptor rs 1799817 aren’t associated with increased risk of CRC.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    37-43
Measures: 
  • Citations: 

    0
  • Views: 

    933
  • Downloads: 

    0
Abstract: 

Background and purpose: Chest X Ray (CXR) is one of the most common radiography uses in the emergency department.24-hour access to trained radiologists is not possible for the emergency residents so this ability is the necessary skills for the students. The precent article evaluates this ability in thr emergency and internal medicine residents.Materials and methods: In the cross-sectional study 11 CXRs with specified interpretation were selected from radiologhic text books and given to emergency medicine residents of three educational hospitals for interpretation. The responses of these individuals to access the research questions were analyzed by statistical software SPSS 18.Results: In total, 114 residents were studied. Average score of emergency residents was 7.2 ± 2.5 (only 65.4% true answer). The mean score of Emergency Medicine in Imam Khomeini Hospital, Rasool Akram and Imam Hossein was 6.4 ± 1.7, 8.5 ± 3.2 and 6.8 ± 3.2 respectively (P=0.001). There was not significant correlation between level of residency and mean score of students (P>0.05).Conclusion: It seems that development in the quality and quantity of radiologic courses is necessary to increase ability of emergency medicine students in CXR interpretation.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    45-50
Measures: 
  • Citations: 

    0
  • Views: 

    860
  • Downloads: 

    0
Abstract: 

Background and purpose: Crimean-Congo hemorrhagic fever is a zoonotic disease that has been reported from different parts of Iran. The aim of this study was to investigate the Seroepidemiology of Crimean-Congo hemorrhagic fever in high risk professions in Yasuj, Iran.Materials and methods: The present study included 108 subjects at risk; 34 butchers, 20 slaughters, 14 slaughter-house workers, 20 waiters, and 20 housewives were randomly selected. After completing the demographic characteristics and history of febrile diseases, blood samples were obtained and specific IgG antibodies against Crimean-Congo hemorrhagic fever virus were tested. The collected data were analyzed with descriptive statistics and percentages and chi-square tests.Results: Of the 108 subjects, 5 (4.6 percent) with positive serology were among restaurant the workers 2 (10 percent) and slaughterers 3 (15 percent), respectively, which was statistically significant.There were no positive serologies in the other groups.Conclusion: The present study showed that the Seroepidemiology of Crimean-Congo hemorrhagic fever in high risk professions is not highly prevalent in Yasuj, Iran. However, the need for further surveillance and prevention programs is still recommended.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    52-62
Measures: 
  • Citations: 

    3
  • Views: 

    1502
  • Downloads: 

    0
Abstract: 

Background and purpose: Pain and fatigue are complications after coronary artery bypass graft surgery. Because of non- pharmacological methods are the preferred pharmacological agent therefore; the purpose of this study was assessment of effect of foot reflexology on pain and fatigue in patients undergoing coronary artery bypass surgery (CABG).Materials and methods: This study was a randomized controlled clinical trial, conducted on 80 patients hospitalized in the Heart Center of Mazandaran in 2011. Sampling was in manner of Non-random and accessible. Patients were age and sex matched and divided randomly in two equal groups of case and control. The reflexology group received 20- minutes left foot massage, from the second day after surgery for 4 consecutive days. In the control group, patient's left foot without applying any pressure and only for 1 minute was fat. Variables pain and fatigue before and after the intervention was recorded by the use of visual analogue scale at the time mentioned. The findings were analyzed by using the software SPSS version 17, descriptive and inferential statistics and tests of x2 and Repeated measurments.Results: Results showed that there is a significant differences in pain levels before and after the intervention between experimental and control groups (P=0.0001). Also, a significant difference confirmed in before and after fatigue levels between experimental and control groups (P=0.0001).Conclusion: According to the study results, Foot reflexology massage, as one of the branches of complementary alternative method can reduce fatigue and pain in CABG patients. Because of its the low cost, the lack of side effects and ease of the procedure to reduce pain and fatigue reflexology massage can be recommended in patients with CABG.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    64-72
Measures: 
  • Citations: 

    3
  • Views: 

    1913
  • Downloads: 

    0
Abstract: 

Background and purpose: In order to identify the impact of aquaculture effluents systems, industrial, agricultural and residential centers, between the output of water from Lar dam up the water input to the Caspian Sea in 7 different stations, river water quality parameters from October 1388 to September 1389 was studied and evaluated with water quality index.Materials and methods: This experimental study was conducted on Haraz River. In order to identify the impact of aquaculture effluents, industrial, agricultural and residential centers, between the output of water from Lar dam up the water input to the Caspian Sea in 7 different stations, river water quality parameters from October 1388 to September 1389 studied and evaluated. Sampling, sample preparation and analysis, according to standard methods (1998) were done.Results: Results of statistical analysis data indicate that the parameters of BOD, TS, EC, turbidity, nitrate, phosphate, and fecal coliform in the effluent entering the river to the plains and the confluence with agricultural and residential centers based on indicators of water quality NSFWQI class average was 70-50 with a range of indicators, while the downstream station (station Sorkhrood) of these indicators in the months except January, June and July reduced to below 50 and as a region with poor water quality (pollution) were identified.Conclusion: Haraz river water at 6 stations (output from Lar dam until Karesang station) based on NSFWQI water quality index evaluated. The range of average quality index was 70-50, while in the downstream stations (station Sorkhrood), the value of these indicators, reduced to below 50, except for the months January, June and July. The station Sorkhrood was identified as an area with poor water quality (pollution).

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    74-81
Measures: 
  • Citations: 

    0
  • Views: 

    2247
  • Downloads: 

    0
Abstract: 

Background and purpose: Chlorhexidine (CHX) is still considered the gold standard antiplaque agent. The main disadvantage of chlorhexidine is its taste, and staining. Improvements of these disadvantages are time consume. This study was to determine if polyvinylpyrrolidone (PVP) could be added to chlorhexidine rinses to maintain efficacy and reduce staining.Materials and methods: This study divided to in vivo and in vitro. The in vivo was randomized, double blind study, and 40 patients with moderate to severe inflammation enrolled to study.The patients undergone dental polishing before the study. In case study and control used e Chlorhexidine +polyvinylpyrrolidone Chlorhexidine mouth wash for 2 weeks respectively. Plaque index (PI) and gingival index (GI), bleeding index (BI), and stain index were assessed before and after the intervention.The glass block and spectrophotometry was used to examine the staining intensity of each mouthwash in In vitro study. The data in SPSS and statistical methods were analyzed by Wilcoxon Signed Ranks Test.Results: PI, GI, BI, stain index difference between base line of Chlorhexidine+polyvinyl pyrrolidone and Chlorhexidine mouthwash group was not significant, But the amount of interference between the two groups was significant difference (P=0.006, 0.007, 0.042 respectively). Final severity of body and gingiva between base line of Chlorhexidine+polyvinylpyrrolidone and Chlorhexidine mouthwash group was significant (P<0.05). Final extent of body and gingiva between base line of two groups was significant (P<0.05).Conclusion: 0.2% concentration of Chlorhexidine and 5% PVP concentration in clinical practice to decrease side effect of Chlorhexidine but maintain Chlorhexidine effect.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    92-96
Measures: 
  • Citations: 

    0
  • Views: 

    1225
  • Downloads: 

    0
Abstract: 

Background and purpose: Chronic rhinosinusitis is a worldwide health concern with almost unknown etiology. In the current investigation, we explored the relation of nasal mucosal and systemic eosinophilia with chronic inflammation to elucidate the role of eosinophils in chronic rhinosinusitis.Materials and methods: The study population included 50 patients with chronic rhinosinusitis.Samples were collected from all patients’ nasal discharge and peripheral venous blood.In the opinion of investigators, exclusion criteria included the conditions that could influencethe immunoglobulins levels such as malignancy, renal dysfunction, vascular diseases, malnutrition, and chemotherapy or radiation therapy. Study was conducted in otorhinolaryngology, head and neck surgery department, Mazandaran University of medical sciences, Sari, Iran from September 2011 to December 2011. Data was analyzed using Cross-Tab and Mann-Whitney tests.Results: The research participants involved 29 (58%) male and 21 (42%) female subjects aged from 5 to 70 years with mean age of 30.6. Nasal mucosal eosinophilia was observed in 42% of the patients (21 participants) and systemic eosinophilia was identified in 15 subjects (30%).42.3% of patients with nasal mucosal eosinophilia and 46.6% of subjects with systemic eosinophilia revealed pan sinusitis in computed tomography scan. There was no significant correlation between blood and mucosal eosinophilia (p=0.29). Post nasal discharge (90%), nasal congestion (52%) and headache (50%) were the commonest clinical symptoms. Nasal septal deviation was reported in 14 patients (28%).Conclusion: In the present study, we concluded patients with nasal mucosal and systemic eosinophilia revealed higher severity of symptoms. Such patients require more clinical care and diagnostic evaluation.

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Author(s): 

KOSARIAN AHMAD SHAHAB | SHAYESTEH AZAR MASOUD | DANESHPOOR SEYED MOHAMMAD MEHDI

Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    98-102
Measures: 
  • Citations: 

    0
  • Views: 

    13548
  • Downloads: 

    0
Abstract: 

Bone growth plates or physis are present at the end of long bones and are responsible for longitudinal growth. These plates consist of 4 layers and are lucent in radiography as a line perpendicular to the longitudinal axis, Because of cartilage layer x-ray absorption is less than calcified bone. Gradually increases with age and bone maturity these line will be narrower and as longitudinal bone growth stops, the line disappears. This phenomenon occurs at different ages in different bones of the skeleton but with complete maturity at the age of 19, all growth plates are closed and sclerosed. Re-appearing after closing is uncommon. We introduce two young patients in this study due to trauma have been treated for an ankle cast and the growth plates of tibia and fibula in their control X-ray was re-appeared. Subchondrel Bone Resorbtion is a known phenomenon that will occur after 6 to 8 weeks immobility in any bone. The lucent line caused by imbalance in osteoblast and osteoclast activity and bone absorption. Re-appearing of growth plates can be caused by reversed ossification and bone absorption.

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    104-107
Measures: 
  • Citations: 

    0
  • Views: 

    710
  • Downloads: 

    0
Abstract: 

Ophthalmomyiasis is pathology of eye due to presence of fly larva, which rarely occurs in the world, and most cases has been reported in developing countries. These days incidence of Ophthalmomyiasis has been decreased in Iran. Most cases of Ophthalmomyiasis caused by presence of fly Larvae Oestrus Ovis.In summer 2011, a fourty year old rural woman with a good hygine presented to Ophthalmology department of Rouhani Hospital. She had no background of any disease.After physical examination External Ophthalmomyiasis was diagnosed. all seven larva has been removed, Topical antibiotic and corticosteroid were prescribed for daily use. Two days later in follow up the eye was asymptomatic.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    22
  • Issue: 

    92
  • Pages: 

    109-135
Measures: 
  • Citations: 

    0
  • Views: 

    4922
  • Downloads: 

    0
Abstract: 

Melanized fungi are frequently considered ubiquitous saprobes commonly found on decomposing plant debris, dead plant material, rotten wood, or soil. Over 70 genera and 150 species of dematiaceous fungi have been implicated in human and animal disease. The clinical syndromes caused by latter fungi are differentiated based on histologic criteria into phaeohyphomycetoma, chromoblastomycosis, and phaeohyphomycosis. Phaeohyphomycosis is a term generally reserved for the remainder of clinical disorder due to black yeast like fungi and relatives. The most important clinical melanized fungi are in the order of Chaetothyriales, e.g.Cladophialophora SPP., Exophiala SPP. and Rinocladiella SPP. Standard conventional diagnostic procedures are direct microscopy, histopathological staining to document tissue invasion, radiographic and computerized tomography (CT) findings. Recently, assays have focused on non-culture based methods, in particular nucleic acid-based methods, such as PCR assays. Most of the invasive infections due to dematiaceous fungi are treating by triazol antifungals, e.g. voriconazole, itraconazole and posaconazole which demonstrated the highest in vitro activity against dematiaceous fungi.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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