STUDY OF HER1, HER2 OVER EXPRESSION IN LOCALLY ADVANCED GASTRIC CANCER AND ITS CORRELATION WITH OVERALL SURVIVAL

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JAN BABAIE GHASEM; NAGHSHVAR FARSHAD; FARAZMANDFAR TOURAJ; SALEHI MOSTAFA; RASHIDI MASOOMEH

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Journal: Journal of Mazandaran University of Medical Sciences Year:2012 | Volume:22 | Issue:92 Page(s): 2-7

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Title

STUDY OF HER1, HER2 OVER EXPRESSION IN LOCALLY ADVANCED GASTRIC CANCER AND ITS CORRELATION WITH OVERALL SURVIVAL

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Keywords

GASTRIC CAQ2

HER1 MARKERQ2

HER2 MARKERQ2

Abstract

Background and purpose: Mortality rate from GASTRIC CAncer is growing in the world.Nowadays, in many cancers, between cancer development and changes in EGF receptor expression levels there is a very precise relationship. Perhaps one of the best known of these changes in GASTRIC CAncer is over expression of Her1 & 2 receptors. This study investigated the expression rate of these two receptors in gastric locally advanced adenocarcinoma, and its correlation with survival of patients.Materials and methods: The samples include 130 paraffin blocks of patients with GASTRIC CAncer in Imam Khomeini Hospital in Sari 1383-88.4 micron sections of tissue blocks were prepared and placed on slides. Then slides were deparaffinized with xylene and dehydrated using alcohol. The endogenous peroxidase activity was inhibited. Her2 Antibody is located on them. Finally, they were stained with hematoxylin.Results: HER1 MARKER only in 23 samples (17.6 %) and HER2 MARKER only in 20 samples (15.4 %) were positive. Accompanying these two markers in 9 patients (6.9 %) was also seen simultaneously. The survey marker Her2 based on sex revealed in 91 male patients, only in 11 cases (11.6 %) and in 39 women only 9 cases (23 %) were positive Conclusion: Expression levels of HER1 MARKER increased with increasing disease stage. These findings may indicate the diagnostic value of this marker in patients with gastric adenocarcinoma.Probably, the rate of HER1 and HER2 receptors expression is associated with invasion and survival of patients.

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APA: Copy

JAN BABAIE, GHASEM, NAGHSHVAR, FARSHAD, FARAZMANDFAR, TOURAJ, SALEHI, MOSTAFA, & RASHIDI, MASOOMEH. (2012). STUDY OF HER1, HER2 OVER EXPRESSION IN LOCALLY ADVANCED GASTRIC CANCER AND ITS CORRELATION WITH OVERALL SURVIVAL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(92), 2-7. SID. https://sid.ir/paper/45224/en

Vancouver: Copy

JAN BABAIE GHASEM, NAGHSHVAR FARSHAD, FARAZMANDFAR TOURAJ, SALEHI MOSTAFA, RASHIDI MASOOMEH. STUDY OF HER1, HER2 OVER EXPRESSION IN LOCALLY ADVANCED GASTRIC CANCER AND ITS CORRELATION WITH OVERALL SURVIVAL. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(92):2-7. Available from: https://sid.ir/paper/45224/en

IEEE: Copy

GHASEM JAN BABAIE, FARSHAD NAGHSHVAR, TOURAJ FARAZMANDFAR, MOSTAFA SALEHI, and MASOOMEH RASHIDI, “STUDY OF HER1, HER2 OVER EXPRESSION IN LOCALLY ADVANCED GASTRIC CANCER AND ITS CORRELATION WITH OVERALL SURVIVAL,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 92, pp. 2–7, 2012, [Online]. Available: https://sid.ir/paper/45224/en

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