ASSOCIATION OF INSULIN RECEPTOR (INSR RS 1799817) WITH COLORECTAL CANCER (CRC)

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KARIMI KHATOON; ARKANI MARAL; SAFAEI AKRAM; VAHEDI MOHSEN; MOHEBI SEYED REZA; FATEMI SEYED REZA; VAFAEI MOHAMAD; ZALI MOHAMMAD REZA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:22 | Issue:92 Page(s): 30-35

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Title

ASSOCIATION OF INSULIN RECEPTOR (INSR RS 1799817) WITH COLORECTAL CANCER (CRC)

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Keywords

COLORECTAL CANCERQ2

INSULIN RECEPTOR GENEQ2

PCR–RFLP J MAZANDQ2

Abstract

Background and purpose: Insulin regulates cell growth and apoptosis by binding to its receptor (INSR).Many studies show that variation in Insulin pathway play a plausible role in the development of CRC. The goal of this study is to evaluate incidence of Insulin Receptor (INSR rs1799817) in Iranian and to investigate the role of this polymorphism in increased risk to CRC.Materials and methods: genotyping of the Insulin Receptor (INSR rs1799817) were determined in a series of 110 COLORECTAL CANCER patients and 110 controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR-RFLP). We use SPSS (V16) for statistical analysis in order to investigate relationship between genotypes and risk of CRC.Results: Results show that polymorphism INSR rs 1799817 is not a predisposing factor to increased risk to CRC (P=0.49). Incidence of mutant allele between patients and controls didn't show significant difference (OR=1.12 95% CI=0.73-1.69).Conclusion: These findings suggest that polymorphism Insulin receptor rs 1799817 aren’t associated with increased risk of CRC.

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APA: Copy

KARIMI, KHATOON, ARKANI, MARAL, SAFAEI, AKRAM, VAHEDI, MOHSEN, MOHEBI, SEYED REZA, FATEMI, SEYED REZA, VAFAEI, MOHAMAD, & ZALI, MOHAMMAD REZA. (2012). ASSOCIATION OF INSULIN RECEPTOR (INSR RS 1799817) WITH COLORECTAL CANCER (CRC). JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(92), 30-35. SID. https://sid.ir/paper/45232/en

Vancouver: Copy

KARIMI KHATOON, ARKANI MARAL, SAFAEI AKRAM, VAHEDI MOHSEN, MOHEBI SEYED REZA, FATEMI SEYED REZA, VAFAEI MOHAMAD, ZALI MOHAMMAD REZA. ASSOCIATION OF INSULIN RECEPTOR (INSR RS 1799817) WITH COLORECTAL CANCER (CRC). JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(92):30-35. Available from: https://sid.ir/paper/45232/en

IEEE: Copy

KHATOON KARIMI, MARAL ARKANI, AKRAM SAFAEI, MOHSEN VAHEDI, SEYED REZA MOHEBI, SEYED REZA FATEMI, MOHAMAD VAFAEI, and MOHAMMAD REZA ZALI, “ASSOCIATION OF INSULIN RECEPTOR (INSR RS 1799817) WITH COLORECTAL CANCER (CRC),” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 92, pp. 30–35, 2012, [Online]. Available: https://sid.ir/paper/45232/en

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