Purpose: The aim of this study was to determine the effect of aerobic exercises on depression, anxiety, life orientation, and happiness of mothers of ADHD children. Methods: Mothers of ADHD children were invited by a public call in Qom city. Of them, 40 subjects were selected through simple random sampling method. Subjects were randomly assigned into two equal experimental and control groups, and then pre-, post-, and follow-up tests were conducted. The experimental group members performed aerobic training for 8 weeks (45 minutes, 3 sessions per week). Anxiety and depression questionnaires of DASS-21 (1995), life orientation of Sheyer & Carver (1985), and Happiness of Oxford (1989) questionnaires were used. The one-way ANCOVA was used to analyze data. Results: Results of the post-and follow-up tests showed that aerobic exercise reduced the depression (P=0. 001) and anxiety (P=0. 001), and increased the life orientation (P=0. 001) and happiness (P=0. 001) of mothers of ADHD children significantly. Conclusion: Without side effects, aerobic exercises may use as an auxiliary way to improve the physical and mental health of mothers with ADHD children, along with other therapies.