Diarrheal diseases is one a leading cm/se of morbidity and mortality in young children in developing countries. Various microorganisms cause diarrhea by several pathogenic mechanisms. It is essential to study the relative of the possible etiologic orgamisms to better underestand the epidemiology of dial7.hea in a community target interventions.There are a number of different diarrhoegenic bacteria of which Enteropathogenic Eshershia Coli (EPEC), Salmonella, Shigella and Kelebsiella are the most widely studied both in developed and developing countiries. Rotavirus is now known to be the most common cause of severe diarrhea in infants and young children, each year causes of illness are reported that leads to hospitalisation. In this study common cause of diarrhea have been studied subclinically for Rotavirus, Salmonella, Shigella, Kelebsiella and Eshershia Coli. 224 children who where under 6 year old have been studied in 1sfahan University hospitals from. Tir to Esfand 1378. Culture methods were used for bacterial identification and specific antiserum was used for serotype determination. ELISA method was used for Rotavirus isolation in stool samples. Electerom Microscope (E.M) the most sensitive methods to Rotavirus identification it was used to evaluation of ELlSA test. Enteropathogens were detected from 224 patients: Rotavirus in 43 patients (19.2%) EPEC in 16 patients (7.1%). Shigella in 1 patient salmonella in 1 patient, non Eshershia Coli EPEC in 23 patient and Klebsiella pneumonia in 8 patient. Mix pathogens were found simultaneously in a number of patients. For example 37 Case of Rotavirus, 12 Case of EPEC, 2 Case of Shigella and 8 Case of Klobsiella were mixed with other cause of diarrhea in this study.