IDENTIFICATION OF MUTATIONS IN EXONS 5 AND 8 OF THE P53 GENE IN PATIENTS AFFECTED WITH COLORECTAL CANCER

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KHEYR ELAHI M.; MAHDIPOUR P.; ATRI M.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2002 | Volume:19 | Issue:63-64 Page(s): 16-23

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Title

IDENTIFICATION OF MUTATIONS IN EXONS 5 AND 8 OF THE P53 GENE IN PATIENTS AFFECTED WITH COLORECTAL CANCER

Author(s)

KHEYR ELAHI M. | MAHDIPOUR P. | ATRI M. | Issue Writer Certificate

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Abstract

P53 gene is a tumour-suppressor gene and produce an m-RNA that is expressed in almost all cell or tissue types of body. Mutations of the P53 tumour suppressor gene observed in 50 to 70% of colorectal carcinomas and several reports have suggested the P53 mutation is a late event.90% of mutations reported in the P53 mutation database have limited their analysis to exons 5 to 8 . The methods used in the current study for the detection of P53 mutation is polymerase chain reaction (PCR) followed by single strand conformation polymorphism (SSCP). In I case of the 20 cases(5%) a shift was detected in exon 5. In 2 cases (10%) altered bands were identified in exon 8. By using "Fisher exact" statical method there is probability of correlation in analysis of several life factor. In according to the results which we got in our studies, rate mutation in exon 5 is equal to 5% and the rate mutation in exon 8 is equal to 10% which these results have perfectly comformity with the results in our studies as before. Our results indicate a difference in mutational spectrum of the P53 gene in distal and proximal colorectal caners. The results of this and another-studies indicate the importance of this gene as a prognostic marker, but there are also many opposite results.

Cites

STUDY OF TWO COMMON P53 GENE MUTATIONS IN GASTRIC CANCER USING PCR-RFLP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, IRAN, 2003

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APA: Copy

KHEYR ELAHI, M., MAHDIPOUR, P., & ATRI, M.. (2002). IDENTIFICATION OF MUTATIONS IN EXONS 5 AND 8 OF THE P53 GENE IN PATIENTS AFFECTED WITH COLORECTAL CANCER. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 19(63-64), 16-23. SID. https://sid.ir/paper/49745/en

Vancouver: Copy

KHEYR ELAHI M., MAHDIPOUR P., ATRI M.. IDENTIFICATION OF MUTATIONS IN EXONS 5 AND 8 OF THE P53 GENE IN PATIENTS AFFECTED WITH COLORECTAL CANCER. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2002;19(63-64):16-23. Available from: https://sid.ir/paper/49745/en

IEEE: Copy

M. KHEYR ELAHI, P. MAHDIPOUR, and M. ATRI, “IDENTIFICATION OF MUTATIONS IN EXONS 5 AND 8 OF THE P53 GENE IN PATIENTS AFFECTED WITH COLORECTAL CANCER,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 19, no. 63-64, pp. 16–23, 2002, [Online]. Available: https://sid.ir/paper/49745/en

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