Purpose: Voltaren (Diclofenac sodium 0.1%) is the first NSAID eye care product approved by FDA for use immediately after cataract surgery to treat ocular inflammation. There are numerous reports of corneal complications of generic Diclofenac (Falcon). This article is aimed at elucidating the impact of Voltaren on tear film of 24 patients with idiopathic episcleritis after a period of 14 days treatment.Materials & Methods: This research designed as a double-blind randomized clinical trial.Baseline values of tear film function of both control and experimental groups obtained through tear breakup time (TBUT) and Schirmer I tests and reassessed on day 15.Voltaren and placebo (normal saline 0.9%) were given to experimental and control groups, respectively. Both groups received Ibuprofen 400mg q8h. Results were analyzed using pooled-t-test.Results: Among 24 patients in experimental group, mean baseline TBUT and Schirmer I values were 15.88 (11-25) seconds and 16.58 (10-35) mm, respectively. At the end of the treatment period, mean TBUT and Schirmer I values measured 14.62 (8-20) seconds and 14.25 (7-31) mm, respectively.In 27 patients of control group, mean baseline TBUT and Schirmer I values were 14.54 (10-22) seconds and 14.58 (10-37) mm, respectively, and on day 15 recorded as 13.62 (9-18) seconds for TBUT and 13.41 (8-25) mm for Schirmer I. A statistically significant difference in schirmer I observed between experimental and control groups (0.89 mm with P=0.008, CI=95%).Conclusion: Despite statistically significant reduction in Schirmer I values among experimental group, it seems to be too small to be clinically important. However, with prolonged application of Voltaren, the impact may become more obvious. Additional time expanded clinical trials are recommended.