A COMPARATIVE CLINICAL TRIAL OF EFFICACY AND SAFETY OF TOPICAL CYCLOSPORINE-A AND MITOMYCIN-C FOR REFRACTORY VERNAL KERATOCONJUNCTIVITIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HASHEMIAN M.N.; RAHIMI F.; MOHAMMADI S.F.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF CURRENT OPHTHALMOLOGY Year:2003 | Volume:16 | Issue:1 Page(s): 101-108

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,001

Download:

Cites:

Information Journal Paper

Title

A COMPARATIVE CLINICAL TRIAL OF EFFICACY AND SAFETY OF TOPICAL CYCLOSPORINE-A AND MITOMYCIN-C FOR REFRACTORY VERNAL KERATOCONJUNCTIVITIS

Author(s)

HASHEMIAN M.N. | RAHIMI F. | MOHAMMADI S.F. | Issue Writer Certificate

Keywords

CYCLOSPORINE-AQ4

MITOMYCIN-CQ4

OCULAR HYPOTONYQ4

PUNCTATE KERATOPATHYQ4

VERNAL KERATOCONJUNCTIVITISQ4

Abstract

Purpose: Comparison of short-term efficacy and safety of topical CYCLOSPORINE-A and MITOMYCIN-C in the treatment of refractory VERNAL KERATOCONJUNCTIVITIS.Methods: A fellow-eye controlled trial in which topical 2% CYCLOSPORINE-A and 0.005% MITOMYCIN-C, four times daily for four weeks were administered concurrently for fellow eyes of 21 patients.Results: CYCLOSPORINE-A brought about significant objective improvement relative to the baseline (P=0.012) and more objective improvement in comparison with MITOMYCIN-C (P=0.046). CYCLOSPORINE-A was associated with a better relative ocular comfort (P=0.003). MITOMYCIN-C was associated with 14 new cases/exacerbations (67%) of PUNCTATE KERATOPATHY and five cases (24%) of hypotony. Hypotony was associated with limbal involvement, disease duration, and severity (P values<0.05). Six patients (29%) reported remarkable burning sensation following application of CYCLOSPORINE-A.Conclusion: Topical MITOMYCIN-C, even at low doses and in the short-term does not seem to be a safe management of VERNAL KERATOCONJUNCTIVITIS as it can result in significant PUNCTATE KERATOPATHY and hypotony. Short-term topical CYCLOSPORINE-A is an efficacious safe adjuvant to current modalities for severe VERNAL KERATOCONJUNCTIVITIS. Its long-term efficacy and safety (including tolerability of its pharmacological formulation) are the areas of future research and development.

Cites

No record.

References

No record.

Cite

APA: Copy

HASHEMIAN, M.N., RAHIMI, F., & MOHAMMADI, S.F.. (2003). A COMPARATIVE CLINICAL TRIAL OF EFFICACY AND SAFETY OF TOPICAL CYCLOSPORINE-A AND MITOMYCIN-C FOR REFRACTORY VERNAL KERATOCONJUNCTIVITIS. JOURNAL OF CURRENT OPHTHALMOLOGY, 16(1), 101-108. SID. https://sid.ir/paper/53192/en

Vancouver: Copy

HASHEMIAN M.N., RAHIMI F., MOHAMMADI S.F.. A COMPARATIVE CLINICAL TRIAL OF EFFICACY AND SAFETY OF TOPICAL CYCLOSPORINE-A AND MITOMYCIN-C FOR REFRACTORY VERNAL KERATOCONJUNCTIVITIS. JOURNAL OF CURRENT OPHTHALMOLOGY[Internet]. 2003;16(1):101-108. Available from: https://sid.ir/paper/53192/en

IEEE: Copy

M.N. HASHEMIAN, F. RAHIMI, and S.F. MOHAMMADI, “A COMPARATIVE CLINICAL TRIAL OF EFFICACY AND SAFETY OF TOPICAL CYCLOSPORINE-A AND MITOMYCIN-C FOR REFRACTORY VERNAL KERATOCONJUNCTIVITIS,” JOURNAL OF CURRENT OPHTHALMOLOGY, vol. 16, no. 1, pp. 101–108, 2003, [Online]. Available: https://sid.ir/paper/53192/en

Related Journal Papers