The aim of the present study was to investigate and compare characteristics of cognitive emotion regulation strategies and general health of university students with and without alexithymia. To do so four hundred and thirty one students were selected by stratified random sampling method from Urmia University. The participants were assessed by using the Cognitive Emotion Regulation Strategies Questionnaire, (CERQ), the General Health Questionnaire (GHQ-28), and Farsi version of the Toronto Alexithymia Scale. From this initial sample, two groups were chosen which consisted of alexithymic (n=75) and nonalexithymic (n=75) groups. Data were analyzed by t-test and multivariate analysis of variance (MANOVA). The findings indicated that there were significant differences between individuals with and without alexithymia. In comparison with nonalexithymia subjects, individual with alexithymia had higher scores in three dimensions of alexithymia (difficulty in describing feelings, difficulty in identifying feelings, and external-oriented thinking style), they used dysfunctional cognitive emotion regulation strategies (self-blame, catastrophazing, and other-blame), and had low general health. By reviewing the constructs of emotion regulation and alexithymia, it can be concluded that alexithymia is likely to be associated with emotion regulation difficulties which may result in a variety of mental health related problems.