Journal of Sabzevar University of Medical Sciences
Year:2001 | Volume:8 | Issue:3 (21)|Papers Count:14

This chinical trial study was conducted to determine the efficiency of different hemodialysis techniques. Three sessions were allocated for each patient; their blood samples were studied at the beginning, 3, 3.5 and 4 hours after the beginning of dialysis. Descriptive and inferential statistics were utilized, especially Repeated ANOVA and Pearson correlation. The results indicated a significant difference between the techniques as for the variant concentrations of BUN and keratin in. The highest decrease was associated with the sixth technique. However, no significant difference was found between the techniques as for the concentrations of potassium, Uric Acid, calcium and Na.

A morphine-6-succinyl-BSA (M-6-S-BSA) hapten was designed in an effort to obtain a potent, long-lasting anti-morphine immune response for the treatment of morphine abuse. The analogue incorporated a succinic anhydride linker moiety in place of hydroxy group at C-6 of the morphine framework. Then morphine 6-hemisuccinate was conjugated to BSA in aqueous solution in the presence of water-soluble carbodi imide. M-6-S-BSA was synthesized in three chemical steps starting from morphine sulphate, and the extent of conjugation was determined by base hydrolysis of the conjugate, extraction and measurement of free morphine. Averages of 6.5 molecules of morphine were conjugated to each molecule of protein. Six rats, Albino wistar strain, immunized with various doses of the conjugate, were found to be producing antibody 8 weeks later, as determined by a modification of the (NH4) 2SO4 method, which measures primary binding of antigen by antibody.

This study involved 40 cases with hypogonadotropic hypogonadism and 30 healthy controls. Relevant data, on their level of the serum calcium, phosphorus, Alkalin phosphatase and testosterone, together with personal information were gathered and put into statistical analysis with SPSS using paired-t-test (P<0.05). The results indicated a significant difference between the two groups as for serum calcium and phosphorus. It was also shown that after puberty, there was no relationship between Alkalin phosphatase and testosterone. Further elaboration on the results may be found in the original study.

Due to the importance of stress as a precipitating factor in mental disorders, this cross-sectional retrospective study was conducted on 80 and 72 bipolar mood disorder (BMD) cases schizophrenic to compare and evaluate their life events. Paykel et al questionnaire was used for data collection; the obtained data were analyzed using p-test and new Mann-Witney U-test. The frequency of life events in BMD cases and schizophrenics were 286 and 296 respectively; the difference was not found to be significant. In these two groups, no significant differences were found between "literate - illiterate" and "single - married" population. Among BMD patients, no significant difference, in the frequency of life events, was found between men and women; whereas, the frequency of life evets in schizophrenic women was significantly higher than their men counterparts. A change in the conditions of the living environment, with a higher frequency in scizophrenics, was the only life event which had a significant difference among the subjects of this study .

The purpose of this quasi-experimental study is to determine the effect of semi-upright position on nausea and vomiting in the canceral patients, who were under chemotherapy in omid hospital of Mashad in 1999. The sample included 91 subjects who were selected purposely. They were studied in two days of chemotherapy period randomly, one day in semiupright and the second day in horizontal position. The parameters of N/V were compared during chemotherapy in two positions (for 4 hours). Chemotherapy and antiemetic regimen in two days were similar. Demographic information and other data were collected about cancer, chemotherapy and vomiting by four point scale. Findings showed that incidence of nausea in semiupright and horizontal position were (48.4%) and (64.8%) respectively; also means of nausea intensity were (11.2±4.5) and (21.19±7.9) ; means of nausea duration were (2.5± 1.4) and (5.3±.4) in the two positions respectively. Paired T-Test showed a significant difference between two positions in all cases. All characteristics of N/V semiupright, in comparison with horizontal position, decreased significantly but did not reach zero. So this safe and simple method is applicable in chemotherapic patients as completion of antiemetic drugs

This quasi-experimental study, involving 48 patients (30 cases and 18 controls) was carried to evaluate the effect of Benson's Relaxation training method on diabetes control in diabetic patients referring to Iran Diabetes Society. The method was practiced with the cases and followed up for 3 months. Chi-square analysis results indicated a significant difference between the two groups in hba1c improvement. Therefore, the first hypothesis was confirmed; however, no significant difference was found to exist between them as for the decrease in insulin dosage (p=0.9). Accordingly, the second hypothesis was rejected.

It is very important to know about ABG in order to evaluate the oxygenation potency of lungs especially in critically ill patients. Many factors such as geographical position do affect ABG. This cross-sectional study was done on 83 healthy young persons having no systemic or other kinds of diseases affecting arterial blood gases. Information on PH, Pao2, ao2, Spo2 and Spo2 were gathered from each person. The obtained results were statistically analyzed using t-test. The mean Pao2 and Paco2 were 111.77 and 41.49 mmHg respectively (see also tables). In the present study, special geographical position of Sari in the vicinity of the Caspian Sea has affected the abovementioned parameters, so that pao2 is much higher. Therefore a higher level of arterial oxygen is to be considered hypoxia in order to prevent the hypoxia risk.

Diabetes during pregnancy is one of the metabolic disorders of pregnancy which may cause serious problems for both mother and fetus if not diagnosed in time. This prospective, cross-sectional study was carried out in Zahedan health clinics to study 2128 pregnant women. WHO recommended methods were used to screen gestational diabetes mellitus (GDM). 96 cases (4.5%) proved positive. Frequency of GDM in different age groups was as follows: 1% in 15-24, 6% in 25-34 years. It was 12% in obese women and 4% in non-obese women. 10% of the cases had a positive family history, while 3.3% had no such history. It was revealed that age, obesity, positive family history of GDM and infant macrosomia correlate with GDM; and age was the most prominent factor. Pregnant women of 25-34 and 35-45 years of age were found to be 4.8 and 12.9 times, respectively, more at risk of GDM than those of 15-24 years of age. Finally, it was concluded that risk factors of age, obesity and familial history of DM were associated together with GDM. GDM is rather prevalent in Zahean and needs to be considered.

The reason for neonatal asphyxia in some cases of amniotic fluid immersed in me conium is not certain. This research has dealt with the relationship of intrauterine development postponement on the basis of Ponderal coefficient and the asphyxia normalities. During the Cohort (future - prospective) study in the Qods nursery of Zahedan, 491 neonates with amniotic fluid emmersed in me conium were investigated and followed up . The results obtained from this survey showed hat Ponderal coefficient displays significant statistical correlation with the early neonatal mortality, intrapartum (P=O.O5), the first minute Apgar and the fifth minute Apgar. But it was observed that it does not display any relationship with the me conium aspiration syndrome (P=0.09) and convulsion (P=0-3). Therefore, it seems that developmental delay could be considered one of the factors which probably render vulnerable the term embryos against the embryonic distresses during delivery and neonatal asphyxia.

Salmonellosis is a contagious infectious disease, the basis of diagnosis of which is the salmonella strain culture. It is an important diagnostic finding so that leucocytes counting more than 10.000/mm3 will provide strong presumptive evidence against such a diagnosis. Leucocyte count usually is not less than 2500/mm3 and severe leucopenia (less than 2000/mm3) is very rare. The case we report here is a 15-year-old girl with symptoms of typhoid fever and positive culture results of blood and stool, for whom leucopenia was reported to be very severe. WBC= 1700, platelet=50.000 and widal (H) =1/1280 . B.M. was negative for malignancy .Special treatment for salmonellosis was effective so that the patient recovered and discharged with normal WBC.