Intralesional bleomycine therapy is an effective method for the treatment of intractable warts. Diverse concentrations of the drug through different methods and protoco1s were used and different success rates were achieved. In this study, we have used a new technique of bleomycine injection to treat intractable warts by multiple puncture technique (MPT). Following the local anaesthesia of 158 warts in 55 patients with recalcitrant common, palmer, periungual, subungual, plantar and mosaic warts, 1 mg/cc bleomycine solution was dropped on the surface of the wart and pricked into the wart by insulin syringe (40 punctures per 5 mm of the wart surface). The treatment, at most four sessions, was carried out once a month. The volume of bleomycine did not exceed 1 ml in each session and 4 mg in four treatments. We found a 83.5% success rate, ranging from 50% in mosaic warts to 91.8% in common warts, which can be compared with the results of previous studies. The technique is easily available and well tolerated with minimal or no complications. As for the success rate, availability, minimal complication and relapse, this technique seems to be an effective, useful, safe and generally well tolerated treatment for recalcitrant warts especially those aforementioned.