The effect of moderate-intensity aerobic training on serum levels of TNF-α,and IL-6 in rats undergoing radiotherapy

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Khaleghi Mina; Mohamadzadeh Salamat Khalid; PARASTESH MOHAMMAD; AZIZBEIGI KAMAL; BAYATIANI MOHAMMAD REZA

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Journal Paper

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Journal: Journal of Shahrekord University of Medical Sciences Year:2021 | Volume:23 | Issue:4 Page(s): 179-183

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Title

The effect of moderate-intensity aerobic training on serum levels of TNF-α,and IL-6 in rats undergoing radiotherapy

Author(s)

Keywords

Radiotherapy

Aerobic exercise

TNF-α

IL-6

Abstract

Background and aims: One of the main potential problems of Radiotherapy (RT) in breast cancer is the increase in treatment-related inflammation. This study aimed to investigate the effect of eight weeks of moderate-intensity aerobic training (AT) on serum levels of tumor necrosis factor α,(TNF-α, ) and interleukin-6 (IL-6) in rats undergoing RT. Materials and Methods: In this experimental study, 32 male rats were randomly divided into four groups of eight members including (1) healthy control (C), (2) AT, (3) RT, and (4) AT + RT groups. Rats were first anesthetized with ketamine-xylazine solution (K, 60-90 kg/mg,Z, 6-10 kg/mg) and then located on a Plexiglas plate with a thickness of 1 cm. Photon beam RT was performed using X-rays with a dose of 11 Gy from an Elekta compact linear accelerator (Elekta Compact 6-MV China). AT program was performed for eight weeks, five days a week, and one session a day for 60 minutes (70-75% of VO2max). Afterwards, one-way ANOVA was run to examine the research variables. Results: According to the results, TNF-α,was significantly higher in the RT group compared to the C group (P = 0. 003), whereas IL-6 levels were significantly lower in the AT + RT group compared to the RT group (P = 0. 001) and the C group (P = 0. 027). Further, the levels of this cytokine were significantly lower in the AT group compared to the RT group (P = 0. 006) and similarly in the RT group compared to the C group (P = 0. 03). Conclusion: RT led to an increase in pro-inflammatory cytokines,however, performing AT could only significantly reduce the IL-6 levels.

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APA: Copy

Khaleghi, Mina, Mohamadzadeh Salamat, Khalid, PARASTESH, MOHAMMAD, AZIZBEIGI, KAMAL, & BAYATIANI, MOHAMMAD REZA. (2021). The effect of moderate-intensity aerobic training on serum levels of TNF-α,and IL-6 in rats undergoing radiotherapy. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 23(4), 179-183. SID. https://sid.ir/paper/1002561/en

Vancouver: Copy

Khaleghi Mina, Mohamadzadeh Salamat Khalid, PARASTESH MOHAMMAD, AZIZBEIGI KAMAL, BAYATIANI MOHAMMAD REZA. The effect of moderate-intensity aerobic training on serum levels of TNF-α,and IL-6 in rats undergoing radiotherapy. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;23(4):179-183. Available from: https://sid.ir/paper/1002561/en

IEEE: Copy

Mina Khaleghi, Khalid Mohamadzadeh Salamat, MOHAMMAD PARASTESH, KAMAL AZIZBEIGI, and MOHAMMAD REZA BAYATIANI, “The effect of moderate-intensity aerobic training on serum levels of TNF-α,and IL-6 in rats undergoing radiotherapy,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 4, pp. 179–183, 2021, [Online]. Available: https://sid.ir/paper/1002561/en

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