Investigation of the effect of early and late breast milk enrichment on growth parameters in preterm infants: A randomized clinical trial

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HAMIDI MAJID; Asadpour Nabiollah; Choopani Roya

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Journal Paper

Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2022 | Volume:24 | Issue:4 Page(s): 168-173

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Title

Investigation of the effect of early and late breast milk enrichment on growth parameters in preterm infants: A randomized clinical trial

Author(s)

HAMIDI MAJID | Asadpour Nabiollah | Choopani Roya | Issue Writer Certificate

Keywords

Preterm infant

Colostrum

Milk fortifier

Abstract

Background and aims: This study aimed to investigate and compare the effect of early and late breast milk fortification on growth parameters in Preterm infants. Methods: In this clinical trial, 90 Preterm infants (28-32 weeks) admitted to the neonatal intensive care unit (NICU) of Hajar Hospital in Shahrekord, Iran were randomly divided into three groups. The fortification was performed when the milk intake reached 30 (group A), 70 (group B), and 100 cc/kg (group C). The height, weight, and head circumference of newborns were measured at the beginning of birth and 4 weeks after the birth. The incidence of sepsis and necrotizing enterocolitis, and milk tolerance were investigated as well. All analyses were conducted with Stata software, and P values < 0. 05 were considered statistically significant. Results: The value changes in the height, weight, and head circumference in all three groups at 4 weeks were significant (P < 0. 001). The mean weight changes in the A, B, and C groups were 727. 33 ±,163. 85, 947. 33 ±,155. 38, and 808. 66 ±,168. 82, indicating a statistically significant difference (P < 0. 001). Further, the mean change of weight after 4 weeks showed statistically significant differences (P < 0. 001) among the A, B, and C groups. The weight gain in the B group was significantly higher than that of the A and C groups (P < 0. 05),however, no significant difference was observed in the mean weight gain between the A and C groups (P = 0. 264). Conclusion: The breast milk fortification when the milk intake reached 70 cc/kg had better efficiency on neonatal weight gain compared with the early and delayed fortification.

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APA: Copy

HAMIDI, MAJID, Asadpour, Nabiollah, & Choopani, Roya. (2022). Investigation of the effect of early and late breast milk enrichment on growth parameters in preterm infants: A randomized clinical trial. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 24(4), 168-173. SID. https://sid.ir/paper/1004096/en

Vancouver: Copy

HAMIDI MAJID, Asadpour Nabiollah, Choopani Roya. Investigation of the effect of early and late breast milk enrichment on growth parameters in preterm infants: A randomized clinical trial. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;24(4):168-173. Available from: https://sid.ir/paper/1004096/en

IEEE: Copy

MAJID HAMIDI, Nabiollah Asadpour, and Roya Choopani, “Investigation of the effect of early and late breast milk enrichment on growth parameters in preterm infants: A randomized clinical trial,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 4, pp. 168–173, 2022, [Online]. Available: https://sid.ir/paper/1004096/en

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