COMPARISON STUDY OF THE DIAGNOSTIC VALUES OF SERUM CYSTATIN C AND CREATININE IN THE ASSESSMENT OF RENAL FUNCTION IN THE EARLY FOLLOW-UP OF RENAL TRANSPLANT PATIENTS

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SOLEYMANI M.J.; ZARGAR SHOUSHTARI M.A.; SHAHROKH H.; HABIB AKHYARI H.; KAFASH NAYERI R.; FERESHTEHNEJAD S.M.; ASGARI MOZHGAN

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Journal: Razi Journal of Medical Sciences Year:2009 | Volume:16 | Issue:63 Page(s): 79-86

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Title

COMPARISON STUDY OF THE DIAGNOSTIC VALUES OF SERUM CYSTATIN C AND CREATININE IN THE ASSESSMENT OF RENAL FUNCTION IN THE EARLY FOLLOW-UP OF RENAL TRANSPLANT PATIENTS

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Keywords

CYSTATIN CQ2

CREATININEQ2

TRANSPLANTED KIDNEYQ3

Abstract

Background & Aim: Early detection of decreasing glomerular filtration rate (GFR) is critical to prevent graft rejection in post-transplantation period. Serum CREATININE has several drawbacks as a marker of GFR, so serum CYSTATIN C has been proposed as an alternative GFR marker. Thus, we prospectively evaluated the diagnostic value of CYSTATIN C measurements compared with serum CREATININE in the early postoperative phase.Patients and Method: In 78 renal recipients, serum CREATININE and CYSTATIN C were measured on the 3rd, 7th and 14th days of post-transplantation period. GFR was established by CREATININE clearance with the cut-off point of 80 ml/min/1.73 m2. The correlation between serum CREATININE and CYSTATIN C with GFR was determined. Sensitivity and specificity of these markers were analyzed by ROC procedures. Results: There were 78 renal recipients (51 males and 27 females) with the mean age of 34. 56± 13.36 years and mean body mass index (BMI) of 22. 36±3.46 kg/m2. Serum CYSTATIN C was not influenced by gender, age and BMI. There was a significant correlation between serum CREATININE and CYSTATIN C levels with GFR on the 3rd, 7th, and 14th days (P< 0. 001). Analysis with ROC procedures showed a decrease in GFR (GFR< 80 ml/min/ 1. 73 m2) on the 7th day (P= 0. 023, AUC= 0. 694). Sensitivity and specificity of serum CYSTATIN C were 67. 7% and 77. 9% respectively with the cut-off point of 2264 ng/ml. Conclusion: CYSTATIN C has good sensitivity to estimate the renal function in the early post transplantation period, but its value as a marker of GFR is decreased at the end of the first week.

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APA: Copy

SOLEYMANI, M.J., ZARGAR SHOUSHTARI, M.A., SHAHROKH, H., HABIB AKHYARI, H., KAFASH NAYERI, R., FERESHTEHNEJAD, S.M., & ASGARI, MOZHGAN. (2009). COMPARISON STUDY OF THE DIAGNOSTIC VALUES OF SERUM CYSTATIN C AND CREATININE IN THE ASSESSMENT OF RENAL FUNCTION IN THE EARLY FOLLOW-UP OF RENAL TRANSPLANT PATIENTS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 16(63), 79-86. SID. https://sid.ir/paper/10059/en

Vancouver: Copy

SOLEYMANI M.J., ZARGAR SHOUSHTARI M.A., SHAHROKH H., HABIB AKHYARI H., KAFASH NAYERI R., FERESHTEHNEJAD S.M., ASGARI MOZHGAN. COMPARISON STUDY OF THE DIAGNOSTIC VALUES OF SERUM CYSTATIN C AND CREATININE IN THE ASSESSMENT OF RENAL FUNCTION IN THE EARLY FOLLOW-UP OF RENAL TRANSPLANT PATIENTS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2009;16(63):79-86. Available from: https://sid.ir/paper/10059/en

IEEE: Copy

M.J. SOLEYMANI, M.A. ZARGAR SHOUSHTARI, H. SHAHROKH, H. HABIB AKHYARI, R. KAFASH NAYERI, S.M. FERESHTEHNEJAD, and MOZHGAN ASGARI, “COMPARISON STUDY OF THE DIAGNOSTIC VALUES OF SERUM CYSTATIN C AND CREATININE IN THE ASSESSMENT OF RENAL FUNCTION IN THE EARLY FOLLOW-UP OF RENAL TRANSPLANT PATIENTS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 16, no. 63, pp. 79–86, 2009, [Online]. Available: https://sid.ir/paper/10059/en

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