Evaluating the expression of IL-17 and IL-23R genes in peripheral blood mononuclear cells in rheumatoid arthritis patients

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SEIF FARHAD; KHOSHMIRSAFA MAJID; MOOSAVI MOHAMMAD; ROUDBARY MARYAM; Khajoei Sholeh; Nikfar Golnaz; Samei Aazam; BAHAR MOHAMMAD ALI; HASHEMZADEH CHALESHTORI MORTEZA; SHIRZAD HEDAYATOLLAH

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Razi Journal of Medical Sciences Year:2018 | Volume:25 | Issue:170 Page(s): 1-8

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

620

Download:

Cites:

Information Journal Paper

Title

Evaluating the expression of IL-17 and IL-23R genes in peripheral blood mononuclear cells in rheumatoid arthritis patients

Author(s)

Keywords

Rheumatoid arthritisQ2

Peripheral blood mononuclear cellsQ1

IL-17Q1

IL-23RQ1

Abstract

Background: Rheumatoid arthritis (RA) is an autoimmune disease caused by accumulation of numerous inflammatory cells in the joints and secretion of various cytokines leading to cartilage and bone damage. IL-17 and IL-23 are inflammatory cytokines that their definite role has not been clearly distinguished in RA pathogenesis. Therefore, this study aimed to investigate the expression and association of IL-17 and IL-23R in Peripheral blood mononuclear cells (PBMCs) in RA patients. Methods: This study was case-control. We gathered peripheral blood from 37 patients with RA and the same number of healthy individuals as a control group. In brief, PBMCs were isolated by Ficoll centrifugation. After RNA extraction and cDNA synthesis, IL-17 and IL-23R expression mRNA levels were determined in PBMCs by real-time PCR technique and Taqman probe method. Results: The mean± standard deviation of the ages in patient group was 46. 86± 1. 328 yr. and in controls was 44. 73± 1. 392 yr. The expression of IL-17 was increased in RA patients in comparison to healthy controls (P= 0. 002). Whereas, after comparison of IL-23R expression in patient and healthy groups, no significant difference was observed (P = 0. 22). Conclusion: In this study, upregulated expression of IL-17 implicated the important role of this cytokine in RA pathogenesis. Therefore, novel therapeutic and more effective strategies can be suggested by further investigations to specifically inhibit IL-17 using monoclonal antibodies (biologic drugs).

Cites

References

No record.

Cite

APA: Copy

SEIF, FARHAD, KHOSHMIRSAFA, MAJID, MOOSAVI, MOHAMMAD, ROUDBARY, MARYAM, Khajoei, Sholeh, Nikfar, Golnaz, Samei, Aazam, BAHAR, MOHAMMAD ALI, HASHEMZADEH CHALESHTORI, MORTEZA, & SHIRZAD, HEDAYATOLLAH. (2018). Evaluating the expression of IL-17 and IL-23R genes in peripheral blood mononuclear cells in rheumatoid arthritis patients. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(170 ), 1-8. SID. https://sid.ir/paper/10068/en

Vancouver: Copy

SEIF FARHAD, KHOSHMIRSAFA MAJID, MOOSAVI MOHAMMAD, ROUDBARY MARYAM, Khajoei Sholeh, Nikfar Golnaz, Samei Aazam, BAHAR MOHAMMAD ALI, HASHEMZADEH CHALESHTORI MORTEZA, SHIRZAD HEDAYATOLLAH. Evaluating the expression of IL-17 and IL-23R genes in peripheral blood mononuclear cells in rheumatoid arthritis patients. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;25(170 ):1-8. Available from: https://sid.ir/paper/10068/en

IEEE: Copy

FARHAD SEIF, MAJID KHOSHMIRSAFA, MOHAMMAD MOOSAVI, MARYAM ROUDBARY, Sholeh Khajoei, Golnaz Nikfar, Aazam Samei, MOHAMMAD ALI BAHAR, MORTEZA HASHEMZADEH CHALESHTORI, and HEDAYATOLLAH SHIRZAD, “Evaluating the expression of IL-17 and IL-23R genes in peripheral blood mononuclear cells in rheumatoid arthritis patients,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 170 , pp. 1–8, 2018, [Online]. Available: https://sid.ir/paper/10068/en

Related Journal Papers