The Effect of Eight Weeks of Resistance Training with Tribulus Terrestris Extract on the Apoptosis Mechanism in the Heart Tissue of Rats Exposed To Stanozolol

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Derakhshandeh Mohammad; TAGHIAN FARZANEH; JALALI DEHKORDI KHOSRO; HOSSEINI SEYED ALI

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Journal: Iranian Journal of Diabetes and Metabolism Year:2022 | Volume:21 | Issue:6 Page(s): 379-389

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Title

The Effect of Eight Weeks of Resistance Training with Tribulus Terrestris Extract on the Apoptosis Mechanism in the Heart Tissue of Rats Exposed To Stanozolol

Author(s)

Derakhshandeh Mohammad | TAGHIAN FARZANEH | JALALI DEHKORDI KHOSRO | HOSSEINI SEYED ALI | Issue Writer Certificate

Keywords

Exercise training

Tribulus Terrestris

Apoptosis

Heart tissue

Stanozolol

Abstract

Background: Artificial intelligence analysis based on the gene list obtained from the DisGeNET database identified the important genes involved in the heart damage process. Data enrichment highlighted the Apoptosis signaling pathway as a vital pathway in cardiovascular risk. Hence, we estimated the binding affinity of chemical and plant bioactive molecules for cytochrome-c protein. Here, we performed to evaluate the effect of eight weeks of resistance training (RT) with Tribulus Terrestris (TT) consumption on the mechanism of Apoptosis in the Heart tissue of rats exposed to Stanozolol. Methods: Thirty-five male rats were divided into seven groups: (1) Control, (2) Stanozolol (ST), (3) ST + 100 mg / kg TT, (4) ST + 50 mg / kg TT, (5) ST + RT (SRT), (6) S + RT + 100 mg / kg T (SRTT100), and (7) ST + RT + 50 mg / kg T (SRTT50). Differential gene expression was measured by q-RT-PCR. In bioinformatics analysis, the Apoptosis signaling pathway was defined as a critical process in heart damage. In addition, adverse effects of Tribulus Terrestris and Stanozolol on Heart tissue were detected through the apoptotic pathway by molecular docking. Result: Resistance training along with 100 mg/kg reduced CRP and cytochrome-c Moreover, 100 mg/kg TT as a more favorable effect than 50 mg/kg TT Conclusion: we showed the beneficial effects of Tribulus Terrestris, the plant’, s bioactive compound that can reduce cardiovascular risks by impairing the formation of apoptosome assemblages and inflammation.

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APA: Copy

Derakhshandeh, Mohammad, TAGHIAN, FARZANEH, JALALI DEHKORDI, KHOSRO, & HOSSEINI, SEYED ALI. (2022). The Effect of Eight Weeks of Resistance Training with Tribulus Terrestris Extract on the Apoptosis Mechanism in the Heart Tissue of Rats Exposed To Stanozolol. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 21(6 ), 379-389. SID. https://sid.ir/paper/1008698/en

Vancouver: Copy

Derakhshandeh Mohammad, TAGHIAN FARZANEH, JALALI DEHKORDI KHOSRO, HOSSEINI SEYED ALI. The Effect of Eight Weeks of Resistance Training with Tribulus Terrestris Extract on the Apoptosis Mechanism in the Heart Tissue of Rats Exposed To Stanozolol. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2022;21(6 ):379-389. Available from: https://sid.ir/paper/1008698/en

IEEE: Copy

Mohammad Derakhshandeh, FARZANEH TAGHIAN, KHOSRO JALALI DEHKORDI, and SEYED ALI HOSSEINI, “The Effect of Eight Weeks of Resistance Training with Tribulus Terrestris Extract on the Apoptosis Mechanism in the Heart Tissue of Rats Exposed To Stanozolol,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 21, no. 6 , pp. 379–389, 2022, [Online]. Available: https://sid.ir/paper/1008698/en

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