The Effect of Resistance Training and Endothelial Stem Cell Injection on Β, eta-Actin, Phosphorylated and Total AKT of Skeletal Muscle in Type 1 Diabetic Rats

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MOKHTARI ELHAM; SARSHIN AMIR; FEIZOLAHI FOAD; Alijani Eidi

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Journal Paper

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Journal: Iranian Journal of Diabetes and Metabolism Year:2022 | Volume:22 | Issue:2 Page(s): 69-80

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Title

The Effect of Resistance Training and Endothelial Stem Cell Injection on Β, eta-Actin, Phosphorylated and Total AKT of Skeletal Muscle in Type 1 Diabetic Rats

Author(s)

MOKHTARI ELHAM | SARSHIN AMIR | FEIZOLAHI FOAD | Alijani Eidi | Issue Writer Certificate

Keywords

Resistance training

Stem cells

Angiogenesis

Type 1 diabetes

Abstract

Background: Type 1 diabetes is associated with decreased skeletal muscle capillary and improper regulation of Angiogenesis pathways in skeletal muscle. This research intended to study the effect of Resistance training and endothelial stem cell injection on β, eta-actin, phosphorylated and total AKT of skeletal muscle in type 1 diabetic rats. Methods: In this experimental study, 36 male Wistar rats (age 6 weeks) were divided into six groups of control (healthy), basal diabetic control, diabetic control, diabetes + stem cell injection, diabetes + Resistance training and diabetes + stem cell injection + Resistance training. In this study, rats became diabetic intraperitoneally using streptozotocin as a single dose of 40 mg/kg. Resistance exercises including climbing a one-meter ladder with weights hanging from the tail were performed for 17 sessions. 500, 000 bone-derived Stem cells were injected by a cell counter. The levels of β, eta-actin, phosphorylated and total AKT in skeletal muscle tissue of rat were measured by using the Western blotting method. Results: The results showed that Resistance training led to significant increase in Pho-AKT, β,-actin and Pho-AKT/AKT ratio and significant decrease in AKT of muscle tissue in type 1 diabetic rats (P<0. 001). Injection of Stem cells leads to significant increase in Pho-AKT and Pho-AKT/AKT ratio and Resistance training with simultaneous injection of Stem cells leads to significant increase in Pho-AKT, β,-actin and significant decrease in Akt of muscle tissue in type 1 diabetic rats (P<0. 001). Conclusion: According to the results, it is possible that the intervention of Resistance training with injection of Stem cells can help regulate the pathways of skeletal muscle Angiogenesis in Type 1 diabetes.

Cites

Prevalence of Diabetic Nephropathy in Patients with Type 1 Diabetes in Iran: A Systematic Review and Meta-Analysis

References

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APA: Copy

MOKHTARI, ELHAM, SARSHIN, AMIR, FEIZOLAHI, FOAD, & Alijani, Eidi. (2022). The Effect of Resistance Training and Endothelial Stem Cell Injection on Β, eta-Actin, Phosphorylated and Total AKT of Skeletal Muscle in Type 1 Diabetic Rats. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 22(2 ), 69-80. SID. https://sid.ir/paper/1008855/en

Vancouver: Copy

MOKHTARI ELHAM, SARSHIN AMIR, FEIZOLAHI FOAD, Alijani Eidi. The Effect of Resistance Training and Endothelial Stem Cell Injection on Β, eta-Actin, Phosphorylated and Total AKT of Skeletal Muscle in Type 1 Diabetic Rats. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2022;22(2 ):69-80. Available from: https://sid.ir/paper/1008855/en

IEEE: Copy

ELHAM MOKHTARI, AMIR SARSHIN, FOAD FEIZOLAHI, and Eidi Alijani, “The Effect of Resistance Training and Endothelial Stem Cell Injection on Β, eta-Actin, Phosphorylated and Total AKT of Skeletal Muscle in Type 1 Diabetic Rats,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 22, no. 2 , pp. 69–80, 2022, [Online]. Available: https://sid.ir/paper/1008855/en

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