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Information Journal Paper

Title

Assessment of Thyroid Function in Children with Beta-Thalassemia Major Referred to Mofid Children’, s Hospital, Tehran, Iran, between 2019-2020

Pages

  63-67

Abstract

 Background and Aim: Thalassemia has been classified by the World Health Organization (WHO) as a major public health problem. Meanwhile, hyperthyroidism is a serious complication and is thought to be associated with iron overload in patients with thalassemia major. The current study aimed to study the function of the thyroid gland in Beta-thalassemia major patients who attended the thalassemia center in Mofid children's hospital of Tehran, Iran. Materials and Methods: The present descriptive study carried out between 2019-2020 to evaluate the function of the thyroid gland in 40 children with Beta-thalassemia major aged between 15-2 years. The demographical information of all the patients was collected and the serum total triiodothyronine (T4), ferritin, and thyroid-stimulating hormone (TSH) levels were measured using enzyme-linked immunosorbent assay (ELISA). All data were included in SPSS columns and were analyzed using descriptive statistics and Chi-square test, t-test, and Mann-Whitney U. Results: The results showed that ferritin level in %52. 5 of patients was ≥,3000 ng/ml. Moreover, %87. 5 of the patients had normal T4 levels (0. 8 to 2 deciliters). Among all patients, subclinical hypothyroidism was the common thyroid dysfunction (%20). Moreover, the most common thyroid dysfunction in patients with normal ferritin levels (≥,3000 ng/ml) was subclinical hypothyroidism (P = 0. 039). Also, the prevalence of hypothyroidism was found to be associated with different age groups (p = 0. 036). Conclusion: It seems that subclinical hypothyroidism is the most common thyroid dysfunction in patients with Beta-thalassemia major. The early detection and treatment of patients could improve their quality of life.

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    APA: Copy

    NAZARI, SHIVA, Sanei Fard, Haddie, & Rezaei, Behandokht. (2022). Assessment of Thyroid Function in Children with Beta-Thalassemia Major Referred to Mofid Children’, s Hospital, Tehran, Iran, between 2019-2020. PAJOUHESH DAR PEZESHKI, 46(1 ), 63-67. SID. https://sid.ir/paper/1009148/en

    Vancouver: Copy

    NAZARI SHIVA, Sanei Fard Haddie, Rezaei Behandokht. Assessment of Thyroid Function in Children with Beta-Thalassemia Major Referred to Mofid Children’, s Hospital, Tehran, Iran, between 2019-2020. PAJOUHESH DAR PEZESHKI[Internet]. 2022;46(1 ):63-67. Available from: https://sid.ir/paper/1009148/en

    IEEE: Copy

    SHIVA NAZARI, Haddie Sanei Fard, and Behandokht Rezaei, “Assessment of Thyroid Function in Children with Beta-Thalassemia Major Referred to Mofid Children’, s Hospital, Tehran, Iran, between 2019-2020,” PAJOUHESH DAR PEZESHKI, vol. 46, no. 1 , pp. 63–67, 2022, [Online]. Available: https://sid.ir/paper/1009148/en

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