Effect of endurance training and glucosamine consumption on gene expression of IGF-1 and IGFBP-3 in knee tissue of mice with acuteosteoarthritis

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Alinejad Mahnaz; BARARI ALIREZA; ABBASI DALOII ASIEH; FARZANEGI PARVIN

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Journal Paper

Paper Information

Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:22 | Issue:3 Page(s): 73-82

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Information Journal Paper

Title

Effect of endurance training and glucosamine consumption on gene expression of IGF-1 and IGFBP-3 in knee tissue of mice with acuteosteoarthritis

Author(s)

Alinejad Mahnaz | BARARI ALIREZA | ABBASI DALOII ASIEH | FARZANEGI PARVIN | Issue Writer Certificate

Keywords

Endurance Training

IGF-1

IGFBP-3

Osteoarthritis

Abstract

Background and Objective: Knee Osteoarthritis is one of the most common causes of musculoskeletal disability. This study was performed to determine the effect of Endurance Training and glucosamine consumption on InsulinLike Growth Factor 1 (IGF-1) and Insulin-Like Growth Factor Binding Protein 3 (IGFBP-3) gene expression in knee tissue of mice with Osteoarthritis. Methods: This experimental study was performed on 30 adult male Wistar rats. Induction of Osteoarthritis of the knee was performed by surgery. The animals were randomly allocated into 5 groups and each group consisted of 6 mice. Groups include: Control, Saline, glucosamine, train and train-glucosamine. The training program for eight weeks, three sessions per week and included 29-25 minutes running on a treadmill at a speed of 15 m/ min for the first week, and each week one meter per minute was added to reach 22 m/min for the eighth week. All animals followed 12-hour fasting and 48 hours after the last session of the session, anesthetized with intraperitoneal injection of Ketamine and Xylosin. The expression of IGF-1 and IGFBP-3 of cartilage was measured by Real Time PCR. Results: Expression of IGF-1 and IGFBP-3 increased to be 22% and 6% in control group compared to Saline group. Also, level of IGF-1 in exercise groups, glucosamine and exercise-glucosamine group was significantly increased compared to control group (P<0. 05). The gene expression of IGFBP-3 in the exercise-glucosamine group was significantly increased compared to the control group (P<0. 05). Conclusion: Probably Chondrocytes secrete higher levels of IGF-1 during tissue damage that causes the structural synthesis of collagen 2 and proteoglycans and Finally, Endurance Training with consumption of glucose amine increases the expression of IGFBP-3 gene.

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APA: Copy

Alinejad, Mahnaz, BARARI, ALIREZA, ABBASI DALOII, ASIEH, & FARZANEGI, PARVIN. (2020). Effect of endurance training and glucosamine consumption on gene expression of IGF-1 and IGFBP-3 in knee tissue of mice with acuteosteoarthritis. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 22(3 (75) ), 73-82. SID. https://sid.ir/paper/1009201/en

Vancouver: Copy

Alinejad Mahnaz, BARARI ALIREZA, ABBASI DALOII ASIEH, FARZANEGI PARVIN. Effect of endurance training and glucosamine consumption on gene expression of IGF-1 and IGFBP-3 in knee tissue of mice with acuteosteoarthritis. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;22(3 (75) ):73-82. Available from: https://sid.ir/paper/1009201/en

IEEE: Copy

Mahnaz Alinejad, ALIREZA BARARI, ASIEH ABBASI DALOII, and PARVIN FARZANEGI, “Effect of endurance training and glucosamine consumption on gene expression of IGF-1 and IGFBP-3 in knee tissue of mice with acuteosteoarthritis,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 3 (75) , pp. 73–82, 2020, [Online]. Available: https://sid.ir/paper/1009201/en

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